Therapeutic use of a carbonic anhydrase enzyme inhibitor for the

Details Therapeutic use of a carbonic anhydrase enzyme inhibitor for the Therapeutic use of a carbonic anhydrase enzyme inhibitor for the

1998-02-13

1999-08-31

Lacyk, John P.

Surgery

Miscellaneous

Methods

A61B 1900

Patent

active

059440210

ABSTRACT:
A method for treating victims of cerebral edema is presented that includes the intravenous injection of a carbonic anhydrase enzyme inhibitor that passes through the blood-brain barrier, such as acetazolamide (A.K.A., DIAMOX.RTM.), which is a readily-available and often-prescribed diuretic. Such edema, or brain swelling may be caused as a result of ischemic strokes especially, but also swelling due to tumors, surgeries, or cerebral trauma. It is preferred to combine the a carbonic anhydrase enzyme inhibitor therapy with hyperventilation of the lungs, even including the use of supplemental oxygen, thereby to reduce the concentration of carbon dioxide in the blood and hence in the brain.

REFERENCES:
patent: 4463208 (1984-07-01), Cragoe, Jr. et al.
patent: 4465850 (1984-08-01), Cragoe, Jr. et al.
patent: 5389630 (1995-02-01), Sato et al.

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