Therapeutic tool for vascular diseases

Details Therapeutic tool for vascular diseases Therapeutic tool for vascular diseases

2006-04-11

2006-04-11

Azpuru, Carols A. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

Reexamination Certificate

active

07025981

ABSTRACT:
The present invention relates to a therapeutic tool for vascular diseases, which is coated with a dye-containing resin that comprises one or more biocompatible dyes selected from the group consisting of sulfonic acid azo dye, phthalein dye, triphenylmethane dye, phenantridium dye, acrydine dye, xanthene dye, phenothiazine dye and cyanine dye; a medical treatment by the use of the therapeutic tool for vascular diseases; and a method of preventing vascular restenosis caused mainly through inhibition of migration of vascular progenitor cells by administering the medical treatment to a subject.Since the present therapeutic tool for vascular diseases is capable of staying in vivo for a long term, a medical treatment such as angioplasty (coronary angioplasty, peripheral angioplasty, cerebral angioplasty, etc.) and blood vessel bypass (coronary bypass, peripheral bypass) by the use of the present tool can effectively inhibit the generation of blood vessel restenosis by inhibiting migration of vascular progenitor cells. Thus, the present tool is extremely useful in clinical situations.

REFERENCES:
patent: 5073071 (1991-12-01), Herwig et al.
patent: 5073171 (1991-12-01), Eaton
patent: 6171609 (2001-01-01), Kunz
C. Di Mario, “New recipes for in-stent restenosis: cut, grate, roast, of sandwich the neointima?” Heart 84:471-475, 2000.
Robert S. Schwartz, MD, “Pathophysiology of Restenosis: Interaction of Thrombosis, Hyperplasia, and/or Remodeling”, Am J Cardiol 81 7A: 14E-17E, Apr. 9, 1998.
Donald Orlic et al, “Mobilized bone marrow cells repair the infarcted heart, improving function and survival”, Proceedings of the National Academy of Sciences of the USA 98:10344-10349, Aug. 28, 2001.
Masataka Sata et al, “Circulating smooth muscle progenitor cells contribute to atherosclerosis”, Nature Medicine 7: 382-383, Apr. 2001.
Koichi Shimizu et al, “Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy”, Nature Medicine vol. 7: 738-741, Jun. 2001.
Yasumi Uchida et al, “Participation of circulating smooth muscle-like cells (cSMLCs) in coronary restenosis after intervention”, Circulation Journal 66 (Supplement I): 273, Apr. 2002.
Masataka Sata et al, “Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis”, Nature Medicine, vol. 8, 403-409, Apr. 2002.

Affiliated with

Also associated with

Rating

Therapeutic tool for vascular diseases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic tool for vascular diseases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic tool for vascular diseases will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3599259