Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2005-10-14
2008-10-21
Foley, Shanon A. (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S185100, C424S265100, C424S268100, C424S272100, C530S300000, C530S350000, C536S023100, C536S023700, C435S069100, C435S069300, C435S173300, C435S320100
Reexamination Certificate
active
07438916
ABSTRACT:
A novel Fasciclin Related Adhesive Protein (FRAP) fromPlasmodiumand related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.
REFERENCES:
patent: WO02/77195 (2002-03-01), None
Matuschewski et al J. Biol. Chem., vol. 277, Issue 44, 41948-41953, Nov. 1, 2002.
Jani Dewal
Nagarkatti Rana
Rathore Dharmendar
Baskar Padma v
Foley Shanon A.
Virginia Tech Intellectual Properties Inc.
Whitham Curtis Christofferson & Cook PC
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