Therapeutic system for the retarded and controlled transdermal o

Details Therapeutic system for the retarded and controlled transdermal o Therapeutic system for the retarded and controlled transdermal o

1990-02-12

1993-06-01

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424449, 424448, A61F 1300

Patent

active

052157512

ABSTRACT:
The present invention relates to a therapeutic system for the retarded and controlled transdermal and transmucous administration of active substances via an impermeable backing layer, an active substance containing reservoir, a substantially drug-free but drug-permeable layer, and a removable protective layer, whereby the drug-free layer is brought into contact with the active substance reservoir only immediately prior or after application and then lies between reservoir and application surface, whereby at least a portion of the active substance diffusing from the reservoir is converted in the retardation layer into a non-bioavailable form. In this connection, the conversion into the non-bioavailable form may be carried out either by immobilization of the active substance, by chemical reactions, or by physical interactions.

REFERENCES:
patent: 4756710 (1988-07-01), Bondi et al.
patent: 4781924 (1988-11-01), Lee et al.
patent: 4810499 (1989-03-01), Nuwayser
patent: 4816258 (1989-03-01), Nedberge et al.

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