Surgery – Respiratory method or device – Ozone or ion generation
Patent
1977-07-12
1980-05-06
Michell, Robert W.
Surgery
Respiratory method or device
Ozone or ion generation
A61F 702
Patent
active
042012112
ABSTRACT:
Therapeutic system in the form of a skin patch that administers clonidine transdermally in an initial priming dose of 10 to 300 mcg/cm.sup.2 of skin that brings the concentration of clonidine in the blood to a level sufficient to elicit alpha-adrenergic stimulation without intolerable side effects, followed by a substantially constant continuous dosage in the range of 0.1 to 100 mcg/hr that maintains said level. The system is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-clonidine reservoir lamina that is the source of the clonidine for the continuous constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-clonidine contact adhesive layer that is the source of the clonidine for the priming dose and the means by which the system is attached to the skin.
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Chandrasekaran Santosh K.
Cleary Gary W.
Darda Siegfried
Michaels Alan S.
ALZA Corporation
Boehringer Ingelheim GmbH
Ciotti Thomas E.
Mandell Edward L.
Michell Robert W.
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