Therapeutic suppression of specific immune responses by administ

Details Therapeutic suppression of specific immune responses by administ Therapeutic suppression of specific immune responses by administ

1988-09-21

1992-06-30

Kepplinger, Esther L.

Drug, bio-affecting and body treating compositions

Lymphokine

424 89, 424 90, 424 91, 424 92, 514 2, 514 8, 514 10, 514 21, 530403, 530402, 530404, 530405, 530406, 530807, 530810, 530813, A61K 39395

Patent

active

051261316

ABSTRACT:
Undesired immune responses are suppressed by administering a nonimmunogenic material which comprises one or more haptens or epitopes corresponding to the antigen which causes the undesired immune response, the number and spacing of the haptens or epitopes being insufficient to trigger an immune response but sufficient to inhibit it. Also disclosed is an improved vaccine from which low molecular weight suppressive polymer has been removed.

REFERENCES:
patent: 3794630 (1974-02-01), Mullan
patent: 3869546 (1975-03-01), Lund
patent: 3919411 (1975-11-01), Glass
patent: 4140679 (1979-02-01), Malley
patent: 4191668 (1980-03-01), Katz
patent: 4253995 (1981-03-01), Katz
patent: 4261973 (1981-04-01), Lee
patent: 4310514 (1982-01-01), Durette
Desaynard, C. et al, Eur. J. Immunol, vol. 5, pp. 541-545 (1975).
Lui, F. et al, Proc. Natl. Acad. Sci, U.S.A., vol. 76(3), pp. 1430-1434 (1979).
Peacock, J. S. et al., J. Immunology, vol. 127(3) pp. 900-906 (1981).
Immunological Reviews, vol. 50, Unresponsivenes To Haptenated Self Structures, Copenhagen (1980).
Immunological Reviews, vol. 43, Mechanism of B Lymphocyte Tolerance, Copenhagen (1979).
Brown, H. M. et al., Acta Allergolagica, vol. 31, pp. 22-34 (1976).
Feldmann, M., J. Exper. Med, vol. 135, pp. 735-753 (1972).
Feldmann, M. et al. Extracellular Matrix Influence on Gene Expression, Academic Press, London (1975).
Perelson, A. A. et al. in Paradoxes in Immunology, Hoffman, G. W. et al. eds, CRC Press, Boca Raton, Fla. (1986), pp. 199-214.
Dintzis et al, "Molecular Determinants of Immunogenicity: The Immunon Model of Immune Response", Proc. Natl. Acad. Sci. U.S.A., vol. 73, No. 10, pp. 3671-3675, Oct. 1976.
"Specific Cellular Stimulation in the Primary Immune Response: A Quantized Model" by B. Vogelstein et al, Proc. Natl. Acad. Sci, U.S.A. vol. 79, pp. 395-399, Jan. 1982.
"Specific Cellular Stimulation in the Primary Immune Response: Experimental Test of a Quantized Model" by R. Z. Dintzis et al, Proc. Natl. Acad. Sci, U.S.A., vol. 79, pp. 884-888, Feb. 1982.
"Studies on the Immunogenicity and Tolerogenicity of T-Independent Antigens", by Renee Z. Dintzis et al, The Journal of Immunology, vol. 131, No. 5, Nov. 1983.
Chiorazzi et al, Proc. Natl. Acad. Sci. U.S.A., vol. 73, No. 6, pp. 2091-2095, Jun. 1976.

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