Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-02-21
2000-02-08
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
4241841, 4241941, 530402, 530403, A61K 39385, C07K 1700
Patent
active
060225440
ABSTRACT:
The invention features a method for reducing an undesired antibody response in a mammal by administering to the mammal a non-immunogenic construct which is free of high molecular weight immunostimulatory molecules. The construct which contains at least two copies of a B cell membrane immunoglobulin receptor epitope bound to a pharmaceutically acceptable non-immunogenic carrier directly binds to B cell membrane immunoglobulin receptors but fails to form an immunon.
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Blodgett James K.
Cheronis John C.
Dintzis Howard M.
Dintzis Renee Z.
Kirschenheuter Gary
Cunningham Thomas M.
The John Hopkins University
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