Therapeutic somatostatin analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530311, 514806, A61K 3702, C07K 726

Patent

active

049046420

ABSTRACT:
An octapeptide of the formula: ##STR1## wherein each A.sub.1 and A.sub.2, independently, is H, C.sub.1-12 alkyl, C.sub.7-10 phenylalkyl, R.sub.1 CO (where R.sub.1 is C.sub.1-20 alkyl, C.sub.3-20 alkenyl, C.sub.3-20 alkinyl, phenyl, naphthyl, or C.sub.7-10 phenylalkyl), or R.sub.2 OCO (where R.sub.2 is C.sub.1-10 alkyl or C.sub.7-10 phenylalkyl), provided that when one of A.sub.1 or A.sub.2 is R.sub.1 CO or R.sub.2 OCO, the other must be H; A.sub.3 is CH.sub.2 -A.sub.6 (where A.sub.6 is pentafluorophenyl, naphthyl, pyridyl, or phenyl); A.sub.4 is o- m- or p-substituted X-Phe (where X is a halogen, H, NO.sub.2, OH, NH.sub.2, or C.sub.1-3 alkyl), pentafluoro-Phe, or .beta.-Nal; A.sub.5 is Thr, Ser, Phe, Val, .alpha.-aminobutyric acid, or Ile, provided that when A.sub.3 is phenyl, A.sub.1 is H, and A.sub.2 is H, A.sub.5 cannot be Val; and A.sub.7 is Thr, Trp, or .beta.-Nal; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4282143 (1981-08-01), Sarantakis
patent: 4291022 (1981-09-01), Sandrin et al.
patent: 4328135 (1982-05-01), Sarantakis
patent: 4395403 (1983-07-01), Bauer et al.
patent: 4435385 (1984-03-01), Bauer et al.
patent: 4485101 (1984-11-01), Coy et al.
Veber et al., Life Sciences, 34:1371-1378 (1984).
Torres-Aleman, Chemical Abstracts 102:160733u (1985).
Schally et al., Proc. Natl. Acad. Sci. USA, 84:7275-7279 (1987).
Siegel et al., Cancer Research, 48:4651-4655 (1988).
Cai, "Synthesis and Evaluation of Activities of Octapeptide Analogs of Somatostatin," Nature, 292:55 (1981).
Lamberts et al., "Potential Role of Somatostatin Analogues in the Treatment of Cancer," European J. of Clin. Invest., 17:281-287 (1987).
Setyono-Han et al., "Direct Inhibitory Effects of Somatostatin (Analogues) on the Growth of Human Breast Cancer Cells," Cancer Research 47:1566 (1987).
Moreau et al., "Therapeutic Advances and Perspectives," Life Sciences, 84:7275-7279 (1987).
Reubi et al., "Somatostatin Receptors in Human Endocrine Tumors," Cancer Research, 47:551-558 (1987).
Murphy et al., Chem. Abstracts 104:28911x (1986).
Cai et al (1985), Proc. 9th Ann. Peptide Symposium Abstr.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic somatostatin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic somatostatin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic somatostatin analogs will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-174233

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.