Therapeutic sepsis treatment using antagonists to PTHrP

Details Therapeutic sepsis treatment using antagonists to PTHrP Therapeutic sepsis treatment using antagonists to PTHrP

1995-06-06

1997-08-26

Housel, James C.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241581, 514885, A61K 39395

Patent

active

056608268

ABSTRACT:
Methods and compositions are provided for the treatment or prophylaxis of systematic inflammatory response syndrome by administering an antagonist to parathyroid hormone-related protein, such as antibodies to PTHrP.

REFERENCES:
patent: 4677070 (1987-06-01), Larrick et al.
patent: 4771124 (1988-09-01), Rosenblatt et al.
patent: 4968669 (1990-11-01), Rosenblatt et al.
patent: 5001223 (1991-03-01), Rosenblatt et al.
patent: 5055447 (1991-10-01), Palladino et al.
patent: 5087561 (1992-02-01), Rosenblatt et al.
patent: 5087562 (1992-02-01), Rosenblatt et al.
patent: 5093233 (1992-03-01), Rosenblatt et al.
patent: 5114843 (1992-05-01), Rosenblatt et al.
patent: 5149779 (1992-09-01), Chorev et al.
patent: 5308834 (1994-05-01), Scott et al.
patent: 5359037 (1994-10-01), Wallach et al.
patent: 5494806 (1996-02-01), Segre et al.
Funk, J.L. et al, Endocrinology, vol. 35(1), 1994, pp. 351-358.
Johansson, A.G. et al, Bone & Mineral, 1994, vol. 24, pp. 25-31.
Caruso, A. et al, E.J. Pharmacol., 1991, vol. 198, pp. 85-88.
Chem. Abst., 118, p. 702 (1993). Abstract 118: 100365w.
Baumgartner et al., "Prevention of Gram-Negative Shock and Death in Surgical Patients by Antibody to Endotoxin Core Glycolipid," The Lancet, pp. 59-63 (Jul. 13, 1985).
Bernhagen et al., "MIF is a Pituitary-Derived Cytokine that Potentiates Lethal Endotoxaemia," Nature, 365, pp. 756-759 (Oct. 1993).
Bertini et al., "Adrenalectomy Sensitizes Mice to the Lethal Effects of Interleukin 1 and Tumor Necrosis Factor," J. Exp. Med., 167, pp. 1708-1712 (May 1988).
Beutler et al., "Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin," Science, 229, pp. 869-871 (Aug. 1985).
Cohen et al., "Antibody Titres to a Rough-Mutant Strain of Escerichia Coli in Patients undergoing Allogeneic Bone-Marrow Transplantation," The Lancelet, pp. 8-10 (Jan. 3, 1987).
Doherty et al., "Evidence for IFN-.gamma. as a Mediator of the Lethality of Endotoxin and Tumor Necrosis Factor-.alpha.," J. Immunology, 149:5, pp. 1666-1670 (Sep. 1992).
Dunn, David L., "Antibody Immunotherapy of Gram-Negative Bacterial Sepsis in an Immunosuppressed Animal Model," Transplantation, 45:2, pp. 424-429 (Feb. 1988).
Funk et al., "Endotoxin Increases Parathyroid Hormone-related Protein mRNA Levels in Mouse Spleen," J. Clin. Investigation, 92, pp. 2546-2552 (Nov. 1993).
Heinzel, Frederick P., "The Role of IFN-.gamma. in the Pathology of Experimental Endotoxemia," J. Immunol., 145:9, pp. 2920-2924 (Nov. 1990).
Jaspers et al., "Antikorper gegen Lipoid A in der Behandlung des septischen Schocks," Infection, 15, Suppl. 2, pp. S89-S95 (1987).
Law and Marks, "Age-Related Prevalence of Human Serum IgG and IgM Antibody to the Core Glycolipid of Escherichia coli strain J5, as Measured by Elisa," J. Infect. Diseases, 151:6, pp. 988-994 (Jun. 1985).
Martin et al., "Parathyroid Hormone-Related Protein: Biochemistry and Molecular Biology," Critical Reviews in Biochemistry and Molecular Biology, 26:3/4, pp. 377-395 (1991).
Ohlsson et al., "Interleukin-1 Receptor Antagonist Reduces Mortality from Endotoxin Shock," Nature, 348, pp. 550-552 (Dec. 1990).
Stewart and Broadus, "Clinical Review 16: Parathyroid Hormone-Related Proteins: Coming of Age in the 1990s," Journal of Clinical Endocrinology and Metabolism, 71:6, pp. 1410-1414 (1990).
Tracey et al., "Anti-cachectin/TNF Monoclonal Antibodies Prevent Septic Shock During Lethal Bacteraemia," Nature, 330, pp. 662-664 (Dec. 1987).
Dinarello, C. A. et al. 1993. "Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome." Journal of the American Medical Association 269:1829-1835.

Affiliated with

Also associated with

Rating

Therapeutic sepsis treatment using antagonists to PTHrP does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic sepsis treatment using antagonists to PTHrP, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic sepsis treatment using antagonists to PTHrP will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1986346