Therapeutic retroviral vectors for gene therapy

Details Therapeutic retroviral vectors for gene therapy Therapeutic retroviral vectors for gene therapy

2011-03-08

2011-03-08

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S320100, C536S024100

Reexamination Certificate

active

07901671

ABSTRACT:
The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.

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