Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-11-12
1996-08-13
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 514912, 514914, 435 4, 435 29, 436 63, A61K 3816, A61K 4900, C12Q 102, G01N 3348
Patent
active
055456170
ABSTRACT:
A method of treating patients suffering from aberrant conjunctival goblet cell mucous secretion associated with a disorder of or injury to the eye is disclosed. The method, which is based on the discovery that conjunctival goblet cell mucous secretion is under the control of the autonomic nervous system, includes administering to an affected eye of a patient a neural system stimulus or inhibitor for sensory, parasympathetic or sympathetic nervous system function. Also disclosed are a therapeutic composition and an article of manufacture including the therapeutic composition useful for carrying out the method of the invention.
REFERENCES:
patent: 4002168 (1977-01-01), Petterson
patent: 4454151 (1984-06-01), Waterbury
patent: 4540408 (1985-09-01), Lloyd
patent: 4745100 (1988-05-01), Gilbard et al.
patent: 4753945 (1988-06-01), Gilbard et al.
patent: 4861760 (1989-08-01), Mazuel et al.
patent: 4868154 (1989-09-01), Gilbard et al.
patent: 4911933 (1990-03-01), Gilbard
patent: 4956348 (1990-09-01), Gilbard et al.
Dartt et al., "Stimulation of Rat Conjunctival Goblet Cell Mucous Secretion,"Journal Cell of Biology 115:15a (1991).
Kessler et al., "Neural stimulaion of conjunctival goblet cell mucous secretion in rats," Abstract. Int'l Conf. on the Lacrimal Gland Tear Film and Dry Eye Syndrome: Basic Science and Clinical Relevance. Southampton Parish, Bermuda. Nov. 14-17, 1992.
Kessler et al., "Effect of adrenergic and agonists ckolinergicc and neural stimulation on goblet cell mucous secretion in rats," ARVO Abstract. Invest. Ophthalmol. Vis. Sci. 34:(Suppl):822 (1993).
Akhtar, "Effects of norepinephrine and 5-hydroxytryptamine on phosphoinositide-PO.sub.4 turnover in rabbit cornea", Exp. Eye Res. 44:849-862 (1987).
Allansmith et al., "Density of goblet cells in vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis", Arch. Ophthalmol. 9884-885 (1981).
Argona et al., "Effects of a stable analogue of PGE.sub.2 (11-deoxy-13,14-didehydro-16(s)-methylester methyl PGE.sub.2 FCE 20700) on the secretory processes of conjunctival goblet cells of rabbit," Exp. Eye Res. 45:647-654 (1987).
Augeron et al., "Neurotensin and neuromedin N stimulate mucin output from human goblet cells (Cl. 16E) via neurotensin receptors," Am. J. Physiol. 262:G470-G476 (1992).
Barnes et al., "Inflammatory mediators and asthma", Pharm. Rev. 40:4984 (1988).
Basbaum et al., "The serous cell," Ann. Rev. Physiol. 52:97-144 (1990).
Braga et al., "Classification of agents that act on bronchial mucus" In: Drugs and Brochial Mucology; edited by PC Braga and L. Allegra, New York: Raven Press, pp. 59-67 (1989).
Butler et al., "Effects of VIIth (facial) nerve degeneration on vasoactive intestinal polypeptide and substance P levels in ocular and orbital tissues of the rabbit", Exp. Eye Res. 39:523-532 (1984).
Carlstedt et al., "Mucous glycoproteins: A gel of a problem", Essays Biochem. 20:40-76 (1985).
Carraway et al., "O-glycosylation pathway for mucin-type glycoproteins," Bioessays 10:117-121 (1989).
Chao et al., "Macromolecular components of human ocular mucus," In: the Preocular Tear Film in Health, Disease and Contact Lens Wear; edited by FJ Holly. TX: Lubbock, Dry Eye Institute; pp. 331-340 (1986).
Chao et al.,"Studies on the isolation and composition of human ocular mucin," Exp. Eye Res: 47:185-196 (1988).
Dartt et al., "Stimulation of Rat Conjunctival Goblet Cell Mucus Secretion," ARVO Abstracts: Invest. Ophthalmol.Civ. Sci. 31(Suppl):408 (1990).
Davis et al., "Goblet cell degranulation in isolated canine tracheal epithelium: response to exogenous ATP,ADP, and adenosine," Am. J. Physiol. 262:C1313-C1323 (1992).
Denis et al., "Autoradiographic characterization and localization of vasoactive intestinal peptide binding sites in abino rat and rabbit eyes," Exp. Eye Res. 52:357-366 (1991).
Dohlman et al., "The glycoprotein (mucus) content of tears from normals and dry eye patients," Exp. Eye Res. 22:35 9-365 (1976).
Friend et al., "Conjunctional goblet cell frequency after alkali injury is not accurately reflected by aqueous tear mucin content," Invest. Othalmol. Vis. Sci. 24:612-618 (1983).
Geggel et al., "Removal of viable sheets of conjunctival epithelium with Dispase II, " Invest. Ophthalmol. Vis. Sci. 26:15-22 (1985).
Gipson, et al., "Characteristics of a glycoprotein in the ocular surface glycocalyx," Invest. Ophthalmol. Vis. Sci. 33:218-227 (1992).
Greiner et al., "Goblet cells of the human conjunctiva," Arch. Opthalmol. 99"2190-2197 (1981).
Greiner et al., "Histochemical analysis of secretory vesicles in nongoblet conjunctival epithelial cells," Acta Ophthalmol. 63:89-92 (1985).
Hoffstein et al., "Leukotriene D.sub.4 (LTD.sub.4) induces mucus secretion from goblet cells in the guinea pig respiratory epithelium," Exp. Lung Res. 16:711-725 (1990).
Holly et al., "Tear physiology and dry eyes," Surv. Ophthalmol. 22:69-87 (1977).
Holtzman "Arachidonic acid metabolism in airway epithelial cells," Annu. Rev. Physiol. 54:303-329 (1992).
Huang et al., "Distribution of conjunctival goblet cells in normal rabbits," Invest. Opthalmol. Vis. Sci. 25(Suppl):322 (1984).
Huang et al., "Morphogenesis of rat conjunctival goblet cells," Invest. Ophthalmol. Vis. Sci. 29:969-975. No date given.
Jensen et al., "Mucosubstances of the acini of the human lacrimal gland (orital part). I. Histochemical identification," Acta Ophthalmol. 47:605-619 (1969).
Jumblatt et al., "Intracellular Mediators of Conjunctival Mucin Secretion," ARVO Abstracts. Invest Ophthalmol. Vis. Sci. 34(Suppl): 822 (1993).
Karjalainen et al., "Catecholamine-containing and acetylcholinesterase-positive nerve fibres in the rabbit conjunctiva," Acta Ophthalmol. 56:911-920 (1978).
Kessing, "Mucous gland system of the conjunctiva," Acta Ophthalmol. 46(Suppl 95):9-133 (1968).
Kim et al., "P.sub.2 punrinoceptor regulation of mucin release by airway goblet cells in primary culture," Br. J. Pharmacal. 103:1053-1056 (1991).
Kinoshita et al., "Goblet cell density in oscular surface disease. A better indicator than tear mucin," Arch Ophthalmol. 101:1284-1287 (1983).
Klyce et al., "Transport processes across the rabbit corneal epithelium: a review," Curr. Eye Res. 4:323-331 (1985).
Kulkarni et al., "Cyclooxygenase and lipoxgenase pathways in anterior uvea and conjunctiva. In: The Oscular Effects of Prostaglandins and Other Eiconsanoids," edited by Bito LX and Stjernshantz J.;Alan R. Liss, Inc; New York,pp. 39-52 (1989).
Kuo et al., "Capsaicin and sensory neurpeptide stimulation of goblet cells secretion in guinea-pig trachea"; J. Physiol 431: 629-641 (1990).
Laburthe et al., "Functional VIP receptors in the human mucus-secreting colonic epithelial cell line CL. 16E," Am. J. Physiol. 256:G443-G450 (1989).
Lamberts, "Physiology of the tear film. In: The Cornea: Scientific Foundations and Clinical Practice," edited by Smolen G. and Thoft RA; Little, Brown and Company, Boston pp. 38-52 (1987).
Latkovic, "The Ultrastructure of the normal conjunctival epithelium of the guinea pig: III. The bulbar zone, the zone of the fornix and the supranodular zone," Acta Ophthalmol. 57:305-320 (1979).
Latkovic, "The ultrastructure of the normal conjunctival epithelium of the guinea pig: IV, The Palpebral and the Perimarginal Zones," Acta Ophthalmol. 57321-335 (1979).
Leikauf et al., "Bradykinin stimulates chloride secretion and prostaglandin E.sub.2 release by canine tracheal epithelium," Am. J. Physiol. 248:F48-F55 (1985).
Lemp, "Basic principles and classifcation of dry eye disorders. In: The Dry Eye:A Comprehensive Guide," edited by Lemp MA and Marquardt R.; Springer-Verlag: Berlin, pp. 101-132 (1992).
Lencer et al., "Interaction of cholera toxin with cloned human goblet cells in monolayer culture," Am. J. Physiol. 258:G96-G102 (1990).
Luhtala et al., "Calcitoningene-related peptide immunoreactive nerve fibers in the rat conjunctiva," Invest. Ophthalmol. Vis. Sci., 32:640-645 (1991).
Luhtala et al., "The distribution and origin of substance P immunoreactive fibres in the rat conjunctiva," Exp. Eye Res. 53:641-646 (1991).
Macintosh, "Innervation of the conjunctiva in monkeys: A
Dartt Darlene A.
Kessler Timothy L.
Degen Nancy J.
Fleisher Mindy
The Schepens Eye Research Institute, Inc.
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