Therapeutic quassinoid preparations with antineoplastic antivira

Details Therapeutic quassinoid preparations with antineoplastic antivira Therapeutic quassinoid preparations with antineoplastic antivira

1997-06-13

1998-12-15

Clardy, S. Mark

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549275, A01N 4312, A61K 3135, C07D40704

Patent

active

058497480

ABSTRACT:
The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.

REFERENCES:
Suntory, Ltd. Abstract of JP 60-104093, 1985.
Yamazaki et al. Abstract of JP 61-200901, 1986.
Cassady et al. Anticancer Agents Based on Natural Product Models. Academic Press. pp. 254-269, 1980.
Kupchan et al. "Structural Requirements for Biological Activity Among Antileukemic Glaucarubolone Ester Quassinoids" J. of Medicinal Chemistry. 19(9):1130-1133, 1976.
Grieco et al. "A Quassinoid (Peninsularinone) and a Steroid from Castela peninsularis" Phytochemistry. 37(5):1451-1454, 1994.
Pierre et al. "Structural Requirements of Quassinoids for the Inhibition of Cell Transformation". Biochemical and Biophysical Research Communications. 93(3):675-686, 1980.
Geissman, T.A., New Substances of Plant Origin, Ann. Rev. Pharmaol., 1964, pp. 305-316.
Nyburg, S. C., Walford, G. L., Yates, P., The Configuration of Glaucarubin, Chem. Commun., 1965, p. 203.
Connolly, J. D., Overton, K. H., The Chemistry and Biochemistry of the Limonoids and Quassinoids, Progress in Phytochemistry, 1970.
Polonsky, Judith, Quassinoids Bitter Principles, Forschr. Chem. Org. Naturst., 1973, pp./101-150.
Kupchan, S. M., Lacadie, J. A., Howie, G. A., Sickles, B.R., Structural Requirements for Biological Activity among Antileukemic Glaucarubolone Ester Quassinoids, J. Med. Chem., 1976, pp. 1130-1133.
Wall, M. E., Wani, M.C., Antineoplastic Agents from Plants, Ann. Rev. Pharmacol, Toxicol., 1977, pp. 117-132.
Seida, Ahmed, et al. Potential Anticancer Agents IX., Lloydia, 1978, pp. 584-587.
Pierre, Alain, et al., Structural Requirements of Quassinoids For the Inhibition of Cell Transformation, Biochem. Biophys. Res. Commun. 1980, pp. 675-686.
Suffness, M. and Douros J., Drugs of Plant Origin, Methods Cancer Research, 1979, 73-126.
Cassady, J. M. Douros, J. D., Anticancer Based on Natural Product Models, Academic Press, 1980, pp. 254-269.
Polonsky, Judith, Chemistry and Biological Activity of the Quassinoids, The Chemistry and Biological Activity of the Quassinoids, The Chemistry and Chemical Taxonomy of the Rutales, Academic Press, Inc., 1983, pp. 247-266.
Polonsky, Judith, Quassinoid Bitter Principles, II, Fortschr. Chem. Org. Naturst., 1985, pp. 221-264.
O'Neill, Melanie J., et al., Plants as Sources of Antimalarial Drugs: In Vitro Antimalarial Activities of Some Quassinoids, Antimicrob. Ag. Chemother., 1986, 101-104.
Lidert, Zev. Wing, Keith, Insect Antifeedant and Growth Inhibitory Activity of Forty-Six Quassinoids on Two Species of Agricultural Pests, Journal of Natural Products, 1987, pp. 442-448.
Corbett, Thomas H. and Valeriote Frederick A., edited by Kallman, PhD, Robert F., Rodent Tumor Models in Experimental Cancer Therapy, Pergamon Press, pp. 233-247, 1987.
Grieco, Paul et al., Total Synthesis of the Highly Oxygenated Quassinoid, Journal of American Chemical Society, 1989 pp. 6287-6294.
Valeriote, Frederick et al., Valeriote, Frederick et al., Cytotoxic anticancer Drugs: Models and Concepts for Drug Discovery and Development, Kluwer Academic Publishers, 1990, 1-87.
Collins, Grieco and Gross, Synthetic Studies on Quassinoids: Total Synthesis of +)-Shinjulactone C, Journal of Organic Chemistry, 1990.
Grieco, Collins, Moher, Fleck and Gross, Synthetic Studies on Quassinoids: Total Synthesis of Chaparrinone, Glaucarubolone and Glaucarubinone, Journal of American Chemical Society, 1993, 6078-93.
Grieco, Moher, Sey, Huffman and Grieco, Quassinoids Peninsularinone and a Steroid From Casatela Peninsularis, Phytochemistry, vol. 37, pp. 1451-1454, 1994.
van Dang, Rode, Stuppner, Quantitative electronic structure-activity relationship (QESAR) of natural cytotoxic compounds: European Journal of Pharmaceutical Sciences, 1994, 331-350.

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