Plant protecting and regulating compositions – Plant growth regulating compositions – Organic active compound containing
Patent
1994-11-04
1997-06-17
Clardy, S. Mark
Plant protecting and regulating compositions
Plant growth regulating compositions
Organic active compound containing
549275, 514453, A01N 4312, A61K 3135, C07D40704
Patent
active
056397127
ABSTRACT:
Quassinoid compounds, compositions, and methods of using them for treating cells and solid tumors, and inhibiting plant growth. The quassinoid derivatives herein are 11,20-epoxy-1,11,12-trihydroxypicras-3-ene-2,16 diones: ##STR1##
REFERENCES:
Suntory, Ltd. Abstract of JP 60-104093 Jun. 1985.
Yamazaki et al. Abstract of JP 61-200901 Sep. 1986.
Geissman, T.A., New Substances of Plant Origin, Ann. Rev. Pharmaol., 1964, pp. 305-316.
Nyburg, S.C., Walford, G.L., yates, P., The Configuration of Glaucarubin, Chem.Commun., 1965, p. 203.
Connolly, J.D., Overton, K.H., The Chemistry and Biochemistry of the Limonoids and Quassinoids, Progress in Phytochemistry, 1970, pp. 385-455.
Polonsky, Judith, Quassinoids Bitter Principles, Forschr. Chem. Org. Naturst., 1973, pp. 101-150.
Kupchan, S. M., Lacadie, J.A., Howie, G.A., Sickles, B.R., Structural Requirements for Biological Activity among Antileukemic Glaucarubolone Ester Quassinoids, J. Med. Chem., 1976, pp. 1130-1133.
Wall, M.E., Wani, M.C., Antineoplastic Agents from Plants, Ann. Rev.Pharmacol. Toxicol., 1977, pp. 117-132.
Seida, Ahmed, et al. Potential Anticancer Agents IX., LLoydia, 1978, pp. 584-587.
Pierre, Alain, et al., Structural Requirements of Quassinoids For the Inhibition of Cell Transformation, Biochem. Biophys. Res. Commun. 1980, pp. 675-686.
Suffness, M. and Douros J., Drugs of Plant origin, Methods Cancer Research, 1979, 73-126.
Cassady, J. M. Douros, J. D., Anticancer Agents Based on Natural Product Models, Academic Press, 1980, pp. 254-269.
Polonsky, Judith, Chemistry and Biological Activity of the Quassinoids, The Chemistry and Chemical Taxonomy of the Rutales, Academic Press, Inc., 1983, pp. 247-266.
Polonsky, Judith, Quassinoid Bitter Principles II, Fortschr. Chem. Org. Naturst., 1985, pp. 221-264.
O'Neill, Melanie J., et al., Plants as Sources of Antimalarial Drugs: In Vitro Antimalarial Activites of Some Quassinoids, Antimicrob. Ag. Chemother., 1986, 101-104.
Lidert, Zev, Wing, Keith, Insect Antifeedant and Growth Inhibitory Activity of Forty-Six Quassinoids on Two Species of Agricultural Pests Journal of Natural Products, 1987, pp. 442-448.
Corbett, Thomas H. and Valeriote Frederick A., edited by Kallman, PhD, Robert F., Rodent Tumor Models in Experimental Cancer Therapy, Pergamon Press, pp. 233-247. 1987.
Grieco, Paul et al., Total Synthesis of the Highly Oxygenated Quassinoid, Journal of American Chemical society, 1989 pp. 6287-6294.
Valeriote, Frederick et al., Cytotoxic anticancer Drugs:Models and Concepts for Drug Discovery and Development, Kluwer Academic Publishers, 1990, 1-87.
Collins, Grieco and Gross, Synthetic Studies on Quassinoids: Total Synthesis of (+)-Shinjulactone C, Journal of Organic Chemistry, 1990, v55. pp. 5816-5818.
Grieco, Collins, Moher, Fleck and Gross, Synthetic Studies on Quassinoids: Total Synthesis of Chaparrinone, Glaucarubolone and Glaucarubinone, Journal of American Chemical Society, 1993, 6078-93.
Grieco, Moher, Sey, Huffman and Grieco, A Quassinoid Peninsularinone and a Steroid From Casatela Peninsularis, Phytochemistry, vol. 37, pp. 1451-1454, 1994.
van Dang, Rode, Stuppner, Quantitative electronic structure-activity relationship (QESAR) of natural cytotoxic compounds: European Journal of Pharmaceutical Sciences, 1994, 331-350.
Corbett Thomas H.
Grieco Paul A.
Morre D. James
Valeriote Frederick A.
Bd. of Governors of Wayne State Univ.
Clardy S. Mark
Indiana University Foundation
Purdue Research Foundation
Reynolds Locke
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