Therapeutic pyrazolyl thienopyridines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S114000

Reexamination Certificate

active

07964612

ABSTRACT:
The present invention provides for compounds of Formula I, and pharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4, R5, R6, and R7have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as therapeutic agents in the treatment of TGFβ-mediated conditions, including cancer and fibrotic disorders. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

REFERENCES:
patent: WO 2006026305 (2006-03-01), None
patent: WO 2006052568 (2006-05-01), None
Berge, et al., Journal of Pharmaceutical Science, “Pharmaceutical Salts”, vol. 66, pp. 1-19, (1977).
O'Kane, et al.,International Journal of Biochemistry&Cell Biology, “Transforming growth factor β s and wound healing”, vol. 29(1), p. 63-78, (1997).
Singh, et al.,Current Opinion in Drug Discovery&Development“Transforming the TGFβ pathway: Convergence of distinct lead generation strategies on a novel kinase pharmacophore for Tβ RI (ALK5)”, vol. 7(4), p. 437-445, (2004).
Wikel et al.,Journal of Hetrocyclic Chemicals, )., “A Convenient Synthesis of the thieno[3,2-c]pryidine Nucleus”, vol. 30 pp. 289-290 (1993).

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