Therapeutic pyrazolonaphthyridine derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S231800, C514S232200, C514S232800, C514S252110, C514S315000, C514S320000, C540S575000, C544S126000, C544S361000, C546S082000

Reexamination Certificate

active

07858614

ABSTRACT:
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAAreceptor and negatively modulating the α5 subtype of GABAA, and use of the compound of formula I for the treatment of GABAAreceptor associated disorders. The general structure of formula I is shown below:The invention further provides a method of modulation of one or more GABAAsubtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).

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