Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-03-07
1982-06-15
Schain, Howard E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424 95, 424105, A61K 3512, A61K 3550, C07G 700
Patent
active
043350402
ABSTRACT:
Described herein are compositions obtained in accordance with the procedure which comprises placing in a pressure vessel a quantity of material comprising animal tissue selected from the group consisting of fresh human placenta or other animal tissues, enclosing and sealing the pressure vessel, maintaining the temperature within the vessel between about 5.degree. C. and less than 60.degree. C. and the pressure greater than about 15 psig and less than about 45 psig over a period from about 2 weeks to about 1 year, opening the vessel at the conclusion of that period and recovering and sterilizing a liquid portion of the semiliquid contents of the vessel. Preferably, the material is maintained in the vessel at a temperature from about 35.degree. C. to about 55.degree. C. and a pressure from about 23 psig to about 37 psig for a period from about 3 to about 4 months. The recovered, sterilized portion can be immediately employed or lyophilized and subsequently reconstituted with, e.g., sterile saline for employment as a therapeutically active agent in the treatment of rheumatoid arthritic and osteoarthritic subjects and for regression of spontaneous benign and malignant neoplasms in mammalian subjects.
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Kiley Thomas D.
Livingston Labs.
Schain Howard E.
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