Therapeutic process with diphosphonate compounds

Details Therapeutic process with diphosphonate compounds Therapeutic process with diphosphonate compounds

1980-11-18

1983-02-01

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

A61K 3166

Patent

active

043715273

ABSTRACT:
A method of increasing the quantity of circulating high density lipoproteins and clearing cholesterol from certain tissues, comprising administering to a human an effective amount of a compound of the formula ##STR1## where X is H, OH, ##STR2## or NH.sub.2 ; R and R' identical or different are H, CH.sub.3 or C.sub.2 H.sub.5 ; m is zero or 1; and A is selected from the group comprising (CH.sub.3).sub.3 C--, Y--C.sub.6 H.sub.4 --, Y--C.sub.6 H.sub.4 --O--C(CH.sub.3).sub.2 --, Y--C.sub.6 H.sub.4 --C(CH.sub.3).sub.2 --, Y--C.sub.6 H.sub.4 --C(O)--C.sub.6 H.sub.4 --, Y--C.sub.6 H.sub.4 --(CH.sub.2).sub.n -- and Y--C.sub.6 H.sub.4 --O--(CH.sub.2).sub.n --, where n is an integer from 1 to 6 and Y is H, CH.sub.3, OCH.sub.3 or Cl.

REFERENCES:
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patent: 3299123 (1967-01-01), Fitch et al.
patent: 3471406 (1969-10-01), Budnik
patent: 4067971 (1978-01-01), Francis
patent: 4113862 (1978-09-01), Fleisch
patent: 4237165 (1980-12-01), Duhault
patent: 4309364 (1982-01-01), Bentzen et al.
Pudovik et al, Index Chemicus, vol. 28, 1968, #89485.
Beaumont, LaNovelle Presse Med. vol. 9, 1980, pp. 3011-3013.
Rouffy et al., Supra pp. 3747-3751.
Ladeger et al., Lipoproteins & Coronary Heart Dis., Creten & Witzstrock Pub., Cologne, 1980 pp. 133-138.
Kaffarnik, et al., Supra pp. 167-168.

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