Therapeutic process employing amides of L and DL phenylglycines

Details Therapeutic process employing amides of L and DL phenylglycines Therapeutic process employing amides of L and DL phenylglycines

1980-02-29

1981-11-10

Cacciapaglia, Jr., Frank

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

424309, 2601125R, A61K 3700, A61K 3124

Patent

active

042998204

ABSTRACT:
Derivates of L- and DL-hydroxyphenylglycines of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or methyl, R.sup.1 is hydrogen, amino or alkoxy having from one to six carbon atoms and R.sup.2 is the residue of certain .alpha.-amino acids are useful in treating diseases and conditions which are characterized by reduced blood flow, oxygen availability or carbohydrate metabolism in the cardiovascular system. Derivatives of D-hydroxyphenylglycine of formula (II) are substantially inactive in treating such diseases and conditions.

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