Therapeutic preparation for inhalation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 3, A61K 3828

Patent

active

057474451

ABSTRACT:
A therapeutic preparation for inhalation which comprises insulin and a substance which enhances the absorption of insulin in the lower respiratory tract, is provided in the form of a powder preparation suitable for inhalation.

REFERENCES:
patent: 3014844 (1961-12-01), Thiel et al.
patent: 4524769 (1985-06-01), Wetterlin
patent: 4534345 (1985-08-01), Wetterlin
patent: 4548922 (1985-10-01), Carey et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4668218 (1987-05-01), Virtanen
patent: 4690952 (1987-09-01), Kagatani et al.
patent: 4746508 (1988-05-01), Carey et al.
patent: 4788221 (1988-11-01), Kagatani et al.
patent: 4847298 (1989-07-01), Alexander
patent: 4895719 (1990-01-01), Radhakrishnan
patent: 4900730 (1990-02-01), Miyauchi
patent: 4907583 (1990-03-01), Wetterlin et al.
patent: 4959358 (1990-09-01), Carey et al.
patent: 4963367 (1990-10-01), Ecanow
patent: 4994439 (1991-02-01), Longenecker
patent: 5006343 (1991-04-01), Benson et al.
patent: 5011678 (1991-04-01), Wang
patent: 5118494 (1992-06-01), Schultz
patent: 5122127 (1992-06-01), Stanley
patent: 5122376 (1992-06-01), Aliverti
patent: 5179079 (1993-01-01), Hansen et al.
patent: 5192548 (1993-03-01), Velasquez et al.
patent: 5200393 (1993-04-01), Weiner
patent: 5202129 (1993-04-01), Samejima et al.
patent: 5254330 (1993-10-01), Ganderton et al.
patent: 5260306 (1993-11-01), Boardman et al.
patent: 5284656 (1994-02-01), Platz et al.
patent: 5288498 (1994-02-01), Stanley et al.
patent: 5341800 (1994-08-01), Clark et al.
patent: 5348730 (1994-09-01), Greenleaf
patent: 5354562 (1994-10-01), Platz et al.
patent: 5364838 (1994-11-01), Rubsamen
patent: 5376386 (1994-12-01), Ganderton et al.
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5419315 (1995-05-01), Rubsamen
patent: 5437271 (1995-08-01), Hodson et al.
patent: 5482032 (1996-01-01), Smith et al.
patent: 5482706 (1996-01-01), Igari et al.
patent: 5506203 (1996-04-01), Backstrom et al.
patent: 5514670 (1996-05-01), Friedman et al.
patent: 5518998 (1996-05-01), Backstrom et al.
Allenby et al., The Absorption of Insulin Across the Respiratory Tract of the Guinea-Pig (U), The Aerosol Society, Fourth Annual Conference 1990, pp. 129-134.
Bjork, Starch Microspheres as a Nasal Delivery System for Drugs, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 103, 1993.
Bjork and Edman, Degradable Starch Microspheres as a Nasal Delivery System for Insulin, Int. J. Pharm. 47:233-238, 1988.
Brange et al., Monomeric Insulins and Their Experimental and Clinical Implications, Diabetes Care 13:923-954, 1990.
Igawa et al., Effect of Absorption Promoters in Intranasal Administration of Human Fibroblast Interferon as a Powder Dosage Form in Rabbits, Chem. Pharm. Bull. 37:418-421, 1989.
Komada et al., Intratracheal Delivery of Peptide and Protein Agents: Absorption from Solution and Dry Powder by Rat Lung, J. Pharm. Sci. 83:863-867, 1994.
Lasker, The Diabetes Control and Complications Trial, N. Engl. J. Med. 329:1035-1036, 1993.
Laube et al., Preliminary Study of the Efficacy of Insulin Aerosol Delivered by Oral Inhalation in Diabetic Patients, JAMA 269:2106-2109, 1993.
Lee et al., Intranasal Bioavailability of Insulin Powder Formulations: Effect of Permeation Enhancer-to-Protein Ratio, J. Pharm. Sci. 80:725-729, 1991.
Mishima et al., Studies on the Promoting Effects of Medium Chain Fatty Acid Salts on the Nasal Absorption of Insulin in Rats, J. Pharma -Dyn. 10:624-631, 1987.
Morita et al., Effects of Various Absorption Promoters on Pulmoary Absorption of Drugs with Different Molecular Weights, Biol. Pharm. Bull. 16:269-262, 1993.
Nagai et al., Powder Dosage Form of Insulin for Nasal Administration, J. Controlled Release 1:15-22, 1984.
"Diabetes Mellitus", Ch. VI in Scientific American Medicine, Scientific American, Inc., Apr. 1993.
The Diabetes Control and Complications Trial Research Group, The Effect of Intensive Treatment of Diabetes on the Development . . . Complications in Insulin-Dependent Diabetes Mellitus, N. Engl. J. Med. 329:977-86, 1993.
Pontiroli et al., Nasal Administration of Glucagon and Human Calcitonin to Healthy Subjects: a Comparison of Different Enhancing Agents, Eur. J. Clin. Pharmacol. 37:427-430, 1989.
Schipper et al., Nasal Insulin Delivery with Dimethyl-.beta.-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective then Liquid Formulations, Pharmaceutical Research 10:682-686, 1993.
Selam and Charles, Devices for Insulin Administration, Diabetes Care 13:955-979, 1990.
Wigley et al., Insulin Across Respiratory Mucosae by Aerosol Delivery, Diabetes 20:552-556, 1971.
Zinman, Medical Intelligence--The Physiologic Relpacement of Insulin, N. Engl. J. Med. 321:363-370, 1989.
Olanoff et al., "Method to Enhance Intranasal Peptide Delivery," in Controlled-Release Technology Pharmaceutical Applications, Lee et al., American Chemical Societ, 301-309, 1987.
Gordon et al.; Nasal Absorption of Insulin: Enhancement by Hydrophobic Bilesalts; Proc. Natl. Acad. Sci.; 82; 7419-7423, 1985.
Zinman; The Physiologic Replacement of Insulin; The New England J. of Med; 321/6; 363-370; 1989.
Ruin, Sydsvenska (Dagbladet), Monday, Jun. 12, 1989, Diabetics May Not Need Their Insulin Shots.
Almer et al., Diabetes Res. and Clin. Pract. 5:s163 (1988).
Bjork, Acta Univ. Uppsala, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 103 (1993).
Timsina et al., Drug Delivery to the Respiratory Tract Using Dry Powder Inhalers, Int. J. Pharmaceutics 101:1-13 (1994).
Schipper et al., Nasal Insulin in Delivery with Dimethyl-.beta.-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations, Pharm. Res. 10:682-686 (1993).
Lee et al., Mucosal Penetration Enhancers for Facilitation of Peptide and Protein Drug Absorption, Critical Rev. Therapeut. Drug Carrier Systems 8:91-192 (1991).
Wearley, Recent Progress in Protein and Peptide Delivery by Noninvasive Routes, Critical Rev. Therapeut. Drug Carrier Systems 8:331-394 (1991).
Dahlback et al., Regional Administration of Drugs to the Rabbit Respiratory Tract, Effects on Absorption, J. Aerosol Medicine 1:222-223 (1988).
Yoshida et al., Absorption of Insulin Delivered to Rabbit Trachea Using Aerosol Dosage Form, J. Pharm. Sci. 68:670-671 (1979).
Damasy et al., Diabetes Res. and Clin. Pract. 5:s163 (1988).
Chandler et al., Nasal Absorption in Rats. II. Effect of Enhancers on Insulin in Absorption and Nasal Histology, Int. J. Pharmaceutics 76:61-70 (1991).
Hirai et al., Effect of Surfactants on the Nasal Absorption of Insulin in Rats, Int. J. Pharmaceutics 9:165-172 (1981).
Gordon et al., Nasal Absorption of Insulin: Enhancement by Hydrophobic Bile Salts, Proc. Natl. Acad. Sci. USA 82:7419-7423 (1985).
Moses et al., Insulin Administered Intranasally as an Insulin-Bile Salt Aerosol, Diabetes 32:1040-47 (1983).
Cutie et al., The Role of Dispersing Agents in Inhalation and Intranasal Aerosol Suspensions, Aerosol. Age 30:52-54 (1985).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic preparation for inhalation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic preparation for inhalation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic preparation for inhalation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-54418

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.