Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives

Details Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives Therapeutic piperazinylalkyl-quinazolone-(4)-derivatives

1971-05-28

1976-10-05

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260251Q, A61K 31505

Patent

active

039845559

ABSTRACT:
Aryl-substituted piperazinylalkyl-quniazolone-(4) derivatives suitable for se as hypotensive, antihistaminic, and analgesic drugs are described. Process for the preparation of the compounds by (1) intra molecular condensation of the product obtained from the reaction of a halogen carboxylanilide with an aryl piperazine; (2) reaction of an .omega.-halogen-alkyl quinazolone with an aryl piperazine; or (3), reaction of an anthranilic acid with a (4-aryl-piperazinyl-(1) carboxylamide, nitride, amidine, or iminoester, followed by alkylation of the product are also described. Pharmaceutical compositions containing the compounds and halogenalkanoic acid-6-carbamyl anilides useful for preparing the compounds are disclosed.

REFERENCES:
Chem. Abst., (1), 68-29720z (1968).
Chem. Abst., (2), 68-103738e (1968).

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