Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1998-02-05
1999-02-23
Criares, Theodore J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
514725, 514458, 514946, 514947, A61K 31045, A61K 3107, A61K 31355
Patent
active
058744797
ABSTRACT:
This invention pertains to therapeutic wound healing compositions for protecting and resuscitating mammalian cells (Embodiment One (I)). This invention also pertains to therapeutic permeation enhanced-wound healing compositions for enhancing the penetration of actives into membranes and increasing the proliferation and resuscitation rate of mammalian cells (Embodiment Two (II)). In a first aspect of Embodiment One (I.A), the therapeutic wound healing composition comprises (a) pyruvate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In a second aspect of Embodiment One (I.B), the therapeutic wound healing composition comprises (a) pyruvate, (b) lactate, and (c) a mixture of saturated and unsaturated fatty acids. In a third aspect of Embodiment One (I.C), the therapeutic wound healing composition comprises (a) an antioxidant and (b) a mixture of saturated and unsaturated fatty acids. In a fourth aspect of Embodiment One (I.D), the therapeutic wound healing composition comprises (a) lactate, (b) an antioxidant, and (c) a mixture of saturated and unsaturated fatty acids. In Embodiment Two (II), the therapeutic wound healing compositions of Embodiment One (I.A-D) are combined with a therapeutically effective amount of a permeation enhancing agent (PE) to form permeation enhanced-wound healing compositions (II.A-D+PE). This invention also pertains to methods for preparing and using the permeation enhanced-wound healing compositions and the topical and ingestible pharmaceutical products in which the therapeutic compositions may be used.
REFERENCES:
patent: 5296307 (1994-03-01), Martin et al.
Barish Jean B.
Criares Theodore J.
Warner-Lambert & Company
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