Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...
Patent
1992-03-30
1995-04-25
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides with at least one nonpeptide bond other than a...
530327, 530328, 530329, 530330, C07K 702, C07K 706
Patent
active
054100194
ABSTRACT:
A linear peptide which is an analog of naturally occurring, biologically active substance P having an active site and a binding site responsible for the binding of the peptide to a receptor on a target cell. The analog has a non-peptide bond instead of a peptide bond between an amino acid residue of the active site and an adjacent amino acid residue, or a synthetic, a .beta.-amino acid, or a .alpha.-amino acid residue replacing two amino acid residues of the active site.
REFERENCES:
patent: 4207311 (1980-06-01), Brown et al.
patent: 4481139 (1984-11-01), Folkers et al.
patent: 4501735 (1985-02-01), Horig et al.
patent: 4737487 (1988-04-01), Watts et al.
patent: 4803261 (1989-02-01), Coy et al.
Cram et al., Organic Chemistry, 2nd Ed. McGraw-Hill Book Company, New York, pp. 607-613 (1964).
Rudingerm, Peptide Hormones, Parsons (Ed) U Park Press, Baltimore, pp. 1-7 (1976).
Coy et al., Tetrahedron, vol. 44, No. 3, pp. 835-841 (1988).
Jensen et al., J. of Physiol. vol. 254: G833 (1988).
Woll et al., "Proc. Natl. Acad. Sci. USA [D-Arg.sup.1, D-Phe.sup.5, D-Trp.sup.7-9 ] Substance P apatent Bombes-n Antagonist in Murine Swiss 3T3 Cells, Inhibits Growth of Human SCLC Cells in vitro," 85:1859 (1988).
Payan, Ann. Rev. Med., "Neuropeptides and Inflammation: The Role of Substance P", 40:341 (1989).
Iverson et al., "The Tachykinin System," Abstract, 11th American Peptide Symposium, (1989).
Tourwe, Janssen Chem. Acta, "The Synthesis of Peptide Analogues with a Modified Peptide Bond", 3:3-15, 17-18 (1985).
Spatola, "Peptide Backbone Modifications," in Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, B., Weinstein, ed., M. Dekkee, New York, and Basel, pp. 267-357 (1983).
Caranikas et al., J. Med. Chem., "Synthesis and Biological Activities of Substance P Antagonists" 25:1313-1316 (1982).
Rosell et al., T.I.P.S., "Substance P Antagonists: A New Type of Pharmacological Tool," 3:211-212 (1982).
Lundberg et al., Proc. Natl. Acad. Sci. USA, "A Substance P Antagonist Inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contra-tion in the guinea pig" 80:1120-1124 (1983).
Engberg et al., Nature, "A Synthetic Peptide as an Antagonist of Substance P" 293:222-223 (1981).
Mizrahi et al., Eur. J. Pharm., Substance P Antagonists Active in Vitro and In Vivo 82:101-105 (1982).
Leander et al., Nature, "A Specific Substance P Antagonist Blocks Smooth Muscle Constrations Induced by Non-Cholinergic non-adrenergic nerve Stimulation" 294-467-469 (1981).
Zhang et al., B.B.A., An Analog of Substance P with Broad Receptor Antagonist Acitivty, 972:37-44 (1988).
Zachary et al., Proc. Natl., Acad. Sci. USA, "High-affinity Receptors for Peptides of the Bombesin Family in Swiss 3T3 Cells," 82:7616-7620.
Coy et al., Tetrahedron, "Solid Phase Reductive Alkylation Techniques in Analogue Peptide Bond and Side Chain Modification" 44:835-841, 1988.
Coy et al., "Progress in the Develipment of of Competitive Bombesin Antagonist", in Abstract of the Intl. Sym. on Bombesin-like Peptides in Health and Disease, Rome, p. 105 (10.87).
Dubreuil et al., "Degradation of the tetragastrin analogue by a membrane fraction from rat gastric mucosa," Drug Design and Delivery 2:49-54, 1987.
Sawyer et al., J. Med. Chem. Design, Stucture-Activity, and Molecular Modeling Studies of Patent Renin Inhibitory Peptides having N-terminal Nin for Trp (FTR) 31:18-30, 1988.
Spatola et al., Tetrahedron, Amide Bond Surrogates: Pseudopeptides and Macrocycles 44:821-833, 1988.
Qian et al., The Journal of Biological Chemistry, vol. 264 pp. 16667-16671 (1989).
Zacharia et al., European Journal of Pharmacology, vol. 203 pp. 353-357 (1991).
Ewenson et al., J. Med. Chem. vol. 31, pp. 416-421 (1988).
Dutta et al., Journal of Med. Chem. vol. 29, No. 7, pp. 1171-1178 (1986).
Lehninger, Principles of Biochemistry, Worth Publishers, Inc., Anderson et al. (Ed.), New York, pp. 95-117 (1982).
Coy David H.
Moreau Jacques-Pierre
Chan Christina Y.
The Administrators of the Tulane-Educational Fund
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