Therapeutic peptides

Details Therapeutic peptides Therapeutic peptides

1984-08-23

1987-03-03

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

C07K 720

Patent

active

046476539

ABSTRACT:
A decapeptide of the formula: Ac-A.sup.1 -A.sup.2 -D-Trp-Ser-Tyr-A.sup.3 -A.sup.4 -A.sup.5 -A.sup.6 -A.sup.7 -NH.sub.2 wherein each A.sup.1 and A.sup.2, independently, is D-Trp, D-.beta.-Nal, or D-p-X-Phe, wherein X is a halogen or CH.sub.3 ; A.sup.3 is D-.beta.-Nal, D-Trp, D-Lys, D-Arg, D-homo-Arg, D-diethyl-homo-Arg, or D-p-X-Phe, wherein X is a halogen or CH.sub.3 ; A.sup.4 is Phe, Tyr, pentafluoro-Phe, Trp, .beta.-Nal, or p-X-Phe, wherein X is a halogen or CH.sub.3 ; A.sup.5 is Arg or Lys; A.sup.6 is Pro or hydroxy-Pro; and A.sup.7 is Gly or D-Ala; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4075191 (1978-02-01), Beddell et al.
patent: 4317815 (1982-03-01), Coy
patent: 4431635 (1984-02-01), Coy
patent: 4444759 (1984-04-01), Rivier et al.
Chemical Abstracts, 103, 74 (1985), Abst. No. 775b.

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