Therapeutic peptide-based constructs derived from Domain II...

Details Therapeutic peptide-based constructs derived from Domain II... Therapeutic peptide-based constructs derived from Domain II...

2005-11-15

2005-11-15

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S015800, C514S016700, C530S326000, C530S327000, C530S328000

Reexamination Certificate

active

06964948

ABSTRACT:
The present invention relates generally to small peptide-based constructs, including derivatized constructs, and their therapeutic uses. The constructs and derivatized constructs can have at least one of heparin binding, heparin neutralizing, endothelial cell proliferation inhibiting, antiangiogenic, LPS binding, LPS neutralization, or antimicrobial properties. The sequences of these constructs are based on a reverse subsequence derived from Domain II of bactericidal/permeability-increasing protein (BPI).

REFERENCES:
patent: 5639727 (1997-06-01), Little, II
patent: 6423825 (2002-07-01), Little, II et al.
patent: 6515104 (2003-02-01), Little, II et al.
patent: WO-97/04008 (1997-02-01), None
Lehninger et al., Biochemistry, 2d ed. (1993) pp. 112-116, 154-155.

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