Therapeutic or prophylactic agent for multiple sclerosis

Details Therapeutic or prophylactic agent for multiple sclerosis Therapeutic or prophylactic agent for multiple sclerosis

2011-02-01

2011-02-01

Fetterolf, Brandon J (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07879837

ABSTRACT:
A therapeutic or prophylactic agent for multiple sclerosis is disclosed. The therapeutic or prophylactic agent comprises as an effective ingredient a glycine derivative having a specific structure or a pharmaceutically acceptable salt thereof, for example, the below-described compound [(E)-2-(2,6-dichlorobenzamido)-5-[4-(isopropyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid]. The therapeutic or prophylactic agent for multiple sclerosis according to the present invention shows the excellent absorbability and in vivo stability when orally administered, and exhibits high therapeutic or prophylactic effects.

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Confavreux et. al., the New England J. Med., 343(20), pp. 1430-1438, (2000), is referenced in this rejection.
David A. Hafler et al., “T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases,” Immunological Reviews, 1987, No. 100, pp. 307-332.
Stephen D. Miller et al., “Experimental Autoimmune Encephalomyelitis in the Mouse”, Current Protocols in Immunology, Unit 15.1, Supplement 19, 1996.
Byron H. Waksman et al., “Multiple Sclerosis as a Disease of Immune Regulation,” Proceedings of the Society for Experimental Biology and Medicine 175, 282-294 (1984).

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