Therapeutic oligonucleotides targeting the human MDR1 and MRP ge

Details Therapeutic oligonucleotides targeting the human MDR1 and MRP ge Therapeutic oligonucleotides targeting the human MDR1 and MRP ge

1995-06-07

1997-11-04

Elliott, George G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 44, 536 231, 536 245, 536 2431, A01N 4304, C07H 2102, C07H 7104, C07H 1904

Patent

active

056839871

ABSTRACT:
The present invention provides novel compositions and methods useful in cancer therapy for inhibiting the multidrug resistance phenotype, which often thwarts long-term chemotherapeutic regimens. The novel compositions of matter comprise oligonucleotides targeted to the human MDR1 and MRP genes, which inhibit expression of these genes, thereby rendering tumors and other forms of cancer more susceptible to the cytotoxic effects of chemotherapeutic agents. Oligonucleotides are also provided that inhibit the multidrug resistance phenotype by exerting an aptameric effect.

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