Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-06-20
2006-06-20
Yu, Misook (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C530S350000
Reexamination Certificate
active
07064193
ABSTRACT:
The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.
REFERENCES:
Genbank Sequence Database (Accession No. AAQ70754), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, publicly available Mar. 22, 1995.
Bowie et al (Science, 1990, 247:1306-1310).
Burgess et al (J of Cell Bio. 111:2129-2138, 1990).
Lazar et al (Molecular and Cellular Biology, 1988, 8:1247-1252).
O'connor et al, (1998, The EMBO Journal, vol. 17, pp. 384-395).
Oltvai et al (Aug. 27, 1993, Cell 73, 609-619).
John C. Reed, “Bcl-2 Family Proteins and the Hormonal Control of Cell Life and Death in Normalcy and Neoplasia.”, Vitamins and Hormones, vol. 53, pp. 99-138, 1997.
Michael D. Jacobson, “Apoptosis: Bcl-2-related proteins get connected.”, Current Biology, vol. 7, No. 5, R277-R281, 1997.
Adams Jerry
Cory Suzanne
Huang David C. S.
O'Connor Liam
O'Reilly Lorraine
Knobbe Martens Olson & Bear LLP
The Walter and Eliza Hall Institute of Medical Research
Yu Misook
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