Therapeutic methods using fusion proteins between interleukin-3

Details Therapeutic methods using fusion proteins between interleukin-3 Therapeutic methods using fusion proteins between interleukin-3

1995-06-06

1999-01-12

Fitzgerald, David L.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

530351, 930141, 4241921, A61K 3820, C12N 1574

Patent

active

058583475

ABSTRACT:
The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C- termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

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