Therapeutic methods for muscular or neuromuscular disorders

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C514S001000, C514S002600, C530S350000

Reexamination Certificate

active

07785587

ABSTRACT:
The disclosure provides methods for treating neuromuscular disorders in mammals. The disclosed methods include administering therapeutically effective amounts of a GDF-8 inhibitor and a corticosteroid to a subject susceptible to, or having, a neuromuscular disorder, so as to maintain desirable levels of muscle function.

REFERENCES:
patent: 4370976 (1983-02-01), Wanchik et al.
patent: 5130141 (1992-07-01), Law et al.
patent: 5562717 (1996-10-01), Tippey et al.
patent: 5639638 (1997-06-01), Wozney et al.
patent: 5700911 (1997-12-01), Wozney et al.
patent: 5723125 (1998-03-01), Chang et al.
patent: 5756457 (1998-05-01), Wang et al.
patent: 5827733 (1998-10-01), Lee et al.
patent: 5914234 (1999-06-01), Lee et al.
patent: 5994618 (1999-11-01), Lee et al.
patent: 6004937 (1999-12-01), Wood et al.
patent: 6096506 (2000-08-01), Lee et al.
patent: 6319505 (2001-11-01), Aoki et al.
patent: 6340668 (2002-01-01), Celeste et al.
patent: 6368597 (2002-04-01), Strassmann et al.
patent: 6369201 (2002-04-01), Barker et al.
patent: 6372454 (2002-04-01), Duan et al.
patent: 6437111 (2002-08-01), Wozney et al.
patent: 6465239 (2002-10-01), Lee et al.
patent: 6607884 (2003-08-01), Lee et al.
patent: 6656475 (2003-12-01), Lee et al.
patent: 6696260 (2004-02-01), Lee et al.
patent: 6835544 (2004-12-01), Mathews et al.
patent: 6891082 (2005-05-01), Lee et al.
patent: 7192717 (2007-03-01), Hill et al.
patent: 7261893 (2007-08-01), Veldman et al.
patent: 7320789 (2008-01-01), Aghajanian et al.
patent: 7381528 (2008-06-01), Lee et al.
patent: 7393682 (2008-07-01), Lee et al.
patent: 2002/0127234 (2002-09-01), El Halawani et al.
patent: 2002/0150577 (2002-10-01), Lee et al.
patent: 2002/0157125 (2002-10-01), Lee et al.
patent: 2003/0074680 (2003-04-01), Lee et al.
patent: 2003/0104406 (2003-06-01), Wolfman et al.
patent: 2003/0138422 (2003-07-01), Aghajanian et al.
patent: 2003/0162714 (2003-08-01), Hill et al.
patent: 2003/0180306 (2003-09-01), Hill et al.
patent: 2004/0055027 (2004-03-01), Lee et al.
patent: 2004/0077053 (2004-04-01), Lee et al.
patent: 2004/0138118 (2004-07-01), Wolfman et al.
patent: 2004/0142382 (2004-07-01), Veldman et al.
patent: 2004/0181033 (2004-09-01), Han et al.
patent: 2004/0223966 (2004-11-01), Wolfman et al.
patent: 2005/0014733 (2005-01-01), Whittemore
patent: 2005/0043232 (2005-02-01), Lee et al.
patent: 2005/0257278 (2005-11-01), Lee et al.
patent: 2006/0240487 (2006-10-01), Nowak et al.
patent: 2006/0240488 (2006-10-01), Nowak et al.
patent: 2008/0178310 (2008-07-01), Lee et al.
patent: 2008/0213426 (2008-09-01), Lee et al.
patent: 1 061 940 (2003-12-01), None
patent: 1 444 985 (2004-08-01), None
patent: WO 94/21681 (1994-09-01), None
patent: WO 94-26892 (1994-11-01), None
patent: WO 96-01845 (1996-01-01), None
patent: WO 98/33887 (1998-08-01), None
patent: WO98/35019 (1998-08-01), None
patent: WO 99/02667 (1999-01-01), None
patent: WO 99/06559 (1999-02-01), None
patent: WO 99/24058 (1999-05-01), None
patent: WO 99/24618 (1999-05-01), None
patent: WO 99/40181 (1999-08-01), None
patent: WO 99/45949 (1999-09-01), None
patent: WO 99/56768 (1999-11-01), None
patent: WO 00/11163 (2000-03-01), None
patent: WO 00/43781 (2000-07-01), None
patent: WO 01/05820 (2001-01-01), None
patent: WO 01-64888 (2001-09-01), None
patent: WO 02/09641 (2002-02-01), None
patent: WO 02/29105 (2002-04-01), None
patent: WO 02/068650 (2002-09-01), None
patent: WO 03/027248 (2003-04-01), None
patent: WO 03/037248 (2003-05-01), None
patent: WO 03/072714 (2003-09-01), None
patent: WO 03/072715 (2003-09-01), None
patent: WO 2004/024092 (2004-03-01), None
patent: WO 2004/037861 (2004-05-01), None
patent: WO2004/037861 (2004-05-01), None
patent: WO 2004/039948 (2004-05-01), None
patent: WO2004/039948 (2004-05-01), None
patent: WO2004-058988 (2004-07-01), None
patent: WO 2004/108157 (2004-12-01), None
patent: WO 2006/020884 (2006-02-01), None
patent: WO 2006/102574 (2006-09-01), None
patent: WO 2006/107611 (2006-10-01), None
Solomon and Bouloux, J. Endocr. 191: 349-360, 2006.
McKenzie et al., Eur. J. Biochem. 269: 2010-2015, 2002.
Reitter B., Brain and Dev.17: 39-43, 1995.
Richard Robinson, Biology, vol. 3, pp. 108-109, 2002.
Haidet et al., PNAS 105: 4318-4322, 2008.
International Search Report, mailed Dec. 6, 2004 for International Patent Application No. PCT/US04/017049.
Granchelli et al., “Pre-Clinical Screening of Drugs Using themdxMouse,”Neuromuscular Disorders10:235-239 (2000).
Hudecki et al., “Strength and Endurance In the Therapeutic Evaluation of Prednisolone-Treated MDX Mice,”Res. Comm. Chem. Path. Pharma.79:45-60 (1993).
Lang et al., “Regulation of Myostatin by Glucocorticoids After Thermal Injury,”FASEB J.15:1807-1809 (2001).
Merlini et al., “Early Prednisone Treatment in Duchenne Muscular Dystrophy,”Muscle&Nerve27:222-227 (2003).
Muntoni et al., “Steroids in Duchenne Muscular Dystrophy: From Clinical Trials to Genomic Research,”Neuromuscular Disorders12:S162-S165 (2002).
Alexander et al., “Human Parathyroid Hormone 1-34 Reverses Bone Loss In Ovariectomized Mice,”J. Bone Miner. Res.16:1665-1673 (2001).
Alliel et al., “Testican, a Multidomain Testicular Proteoglycan Resembling Modulators of Cell Social Behaviour,”Eur. J. Biochem.214:347-350 (1993).
Amthor et al., “The Expression and Regulation of Follistatin and a Follistatin-like Gene During Avian Somite Compartmentalization and Myogenesis,”Dev. Biol.178:343-362 (1996).
Andersson et al., “Repeated In Vivo Determinations of Bone Mineral Density During Parathyroid Hormone Treatment in Ovariectomized Mice,”J. Endocrinol.170:529-537 (2001).
Attisano et al., “Activation of Signalling by the Activin Receptor Complex,”Mol. Cell. Biol.16:1066-1073 (1996).
Bartholin et al., “FLRG, an Activin-Binding Protein, is a New Target of TGFβ Transcription Activation Through Smad Proteins,”Oncogene20:5409-5419 (2001).
Brown et al., “Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3,”Growth Factors3:35-43 (1990).
D'Angelo et al., “Authentic Matrix Vesicles Contain Active Metalloproteases (MMP),”J. Biol. Chem.276:11347-11353 (2001).
Derynck et al., “Human Transforming Growth Factor-β Complementary DNA Sequence and Expression in Normal and Transformed Cells,”Nature316:701-705 (1985).
Donoghue et al., “Rostrocaudal Gradient of Transgene Expression in Adult Skeletal Muscle,”Proc. Natl. Acad. Sci. U.S.A.88:5847-5851 (1991).
Gamer et al., “Gdf11 is a Negative Regulator of Chondrogenesis and Myogenesis in the Developing Chick Limb,”Dev. Biol.229:407-420 (2001).
Gentry et al., “The Pro Domain of Pre-Pro-Transforming Growth Factor β1 When Independently Expressed Is a Functional Binding Protein for the Mature Growth Factor,”Biochemistry29:6851-6857 (1990).
Hayette et al., “FLRG (Follistatin-Related Gene), A New Target of Chromosomal Rearrangement in Malignant Blood Disorders,”Oncogene16:2949-2954 (1998).
Hoodless et al., “Mechanisms and Function of Signaling by the TGFβ Superfamily,”Curr. Top. Microbiol. Immunol.228:236-272 (1998).
Huet et al., “Skeletal Muscle Cell Hypertrophy Induced by Inhibitors of Metalloproteases; Myostatin as a Potential Mediator,”Am. J. Physiol. Cell. Physiol.281:C1624-C1634 (2001).
Jiang et al., “Characterization and Identification of the Inhibitory Domain of GDF-8 Propeptide,”Biochem. Biophys. Res. Commun.315:525-531 (2004).
Kato, “A Secreted Tumor-Suppressor, mac25, with Activin-Binding Activity,”Mol. Med.6:126-135 (2000).
Kessler et al., “Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinase,”Science271:360-362 (1996).
Kingsley, D.M., “The TGF-β Superfamily: New Members, New Receptors, and New Genetic Tests of Function in Different Organisms,”Genes Dev.8:133-146 (1994).
Lee et al., “Analysis of Site-Directed Mutations

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