Chemistry: analytical and immunological testing – For preexisting immune complex or auto-immune disease – Antinuclear
Patent
1997-06-23
2000-06-27
Scheiner, Laurie
Chemistry: analytical and immunological testing
For preexisting immune complex or auto-immune disease
Antinuclear
436506, 4241401, 4241841, G01N 33564
Patent
active
060805889
ABSTRACT:
This invention provides an antibody with high affinity for single-stranded DNA, low or no affinity for double-stranded DNA, and capable of specifically binding a DNA hairpin and the hybridoma cell lines which produces these monoclonal antibodies. A chimeric mouse comprising these hybridoma cell lines and a histocompatible mouse is further provided. A method for screening for an agent which will inhibit anti-DNA antibody.cndot.DNA binding. One such agent is a benzodiazepine derivative. This invention therefore provides a method of inhibiting the binding of an anti-DNA antibody to its DNA ligand in a sample by contacting the sample with an effective amount of a benzodiazepine derivative.
REFERENCES:
patent: 4690905 (1987-09-01), Diamond
patent: 5225326 (1993-07-01), Bresser et al.
Andrzejewski, C., Jr., et al., "Antigen-Binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA" (1981) J. Immunol. 126(1):226-231. (Abstract only).
Ballard, D., et al., "Base specificity and idiotypy of anti-DNA Autoantibodies reactive with synthetic nucleic acids" (1985) J. Immunol. 135(5):3372-3380.
Ben-Chetrit, E., et al., "Specific inhibition of the DNA anti-DNA immune reaction by low molecular weight anionic compounds" (1988) Immunology 65:479-485.
Brinkman, K., et al., "Anti-DNA antibodies and lupus nephritis: The complexity of cross-reactivity" (1990) Immunology Today 11:232-234.
Campbell, "Monoclonal Antibody Technology" in Laboratory Techniques in Biochemistry and Molecular Biology, Burdon et al., Eds., New York, Elsevier (1984) vol. 13, pp. 168-169.
Chmielewski et al., "Monoclonal antibodies with sequence specific affinity for a stem-loop structure in DNA" (1991) Tetrahedron 47(14/15):2563-2572.
Edberg, J.C., et al., "Quantitative aspects of lupus anti-DNA autoantibody specificity" (1986) J. Immunol. 136:4581-4587.
Eilat, D., "Cross-reactions of anti-DNA and the central dogma of lupus nephritis" (1985) Immunology Today 6:123-127.
Eilat, D., "Monoclonal autoantibodies: An approach to studying autoimmune disease" (1982) Mol. Immunol. 19(7):943-955.
Eilat, D., et al., "Structure-function correlates of autoantibodies to nucleic acids: Lessons from immunochemical, genetic and structural studies" (1994) Mol. Immunol. 184:1377-1390.
Foster, M.H., et al., "Nephritogenic autoantibodies in systemic lupus erythematosus: Immunochemical properties, mechanisms of immune deposition, and genetic origins" (1993) Lab. Invest. 69:494-507.
Fukada et al., "Monoclonal anti-DNA antibody: Preparation and availability" Nucl. Acids Res. (1988) Symposium Series No. 19, pp. 69-72.
Glick, G.D., et al., "Trapping and isolation of an alternate DNA conformation" (1992) J. Am. Chem. Soc. 114:5447-5448.
Herron, J.N., et al., "An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex" (1991) Proteins 11:159-175.
Isenberg D.A., et al., "The origin, sequence, structure and consequences of developing anti-DNA antibodies: A human perspective" (1994) Arthritis Rheum. 37:169-180.
Koffler, D., et al., "Immunological studies concerning the nephritis of systemic lupus erythematosus" (1967) J. Exp. Med. 126:607-623.
Koffler, D., et al. "Antibodies to polynucleotides in human sera: antigenic specificity and relation to disease" (1971) J. Exp. Med. 134:294-312.
Lafer, E.M., et al., "Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids" (1981) J. Exp. Med. 153(4):897-909. (Abstract only).
Lee, J., et al., "Specificity of autoimmune monoclonal Fab fragments binding to single-stranded deoxyribonucleic acid" Biochem. (1982) 21:4940-4945.
Papalian, M., et al., "Reaction of systemic lupus erythematosus anti-native DNA antibodies with native DNA fragments from 20 to 1200 base pairs" (1980) J. Clin. Invest. 65:469-477.
Pisetsky, D., et al., "Binding specificity of a monoclonal anti-DNA antibody" (1982) Mol. Immunol. 19(5):645-650. (Abstract only).
Pollard, K., et al., "Polynucleotide specificities of murine monoclonal anti-DNA antibodies" (1986) Clin. Immunol. Immunopathol. 40(2):197-208. (Abstract only).
Radic, M.Z., et al., "Genetic and Structural evidence for antigen selection of anti-DNA antibodies" (1994) Ann. Rev. Immunol. 12:487-520.
Radic, M.Z., et al., "Residues that mediate DNA binding of autoimmune antibodies" (1993) J. Immunol. 150:4966-4977.
Rumbley, C.A., et al., "Construction, characterization, and selected site-specific mutagenesis of an anti-single-stranded DNA single-chain autoantibody" (1993) J. Biol. Chem. 268:13667-13674.
Stevens, S.Y., et al., "Application of the gel shift assay to study the affinity and specificity of anti-DNA antibodies" (1994) J. Immunol. Methods 177:185-190.
Stevens, S.Y., et al., "Evidence for induced fit in antibody-DNA complexes" (1993) J. Am. Chem. Soc. 115:1585-1586.
Stollar, D., et al., "The antigenic determinants of denatured DNA reactive with lupus erythematosus serum" (1962) Proc. Natl. Acad. Sci. USA 48:874-880.
Swanson et al., "Ligand recognition by murine anti-DNA autoantibodies II." J. Clin. Invest. (1996) 97(7):1748-1760.
Swanson, P.C., et al., "High resolution epitope mapping of an anti-DNA autoantibody using model DNA Ligands" (1994) J. Immunol. 152(5):2601-2612.
Tan, E.M., "Antinuclear antobodies: diagnostic markers for autoimmune diseases and probes for cell biology" (1989) Adv. Immunol. 44:93-151.
Termaat, J-H., et al., "Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms" (1992) Kidney Intl. 42:1363-1371.
Tetin, S.Y., et al., "Elucidation of anti ssDNA autoantibody BVO4-01 binding interactions with homooligonucleotides" (1993) Biochemistry 32:9011-9017.
Tsao, B.P., et al., "Structural characteristics of the variable regions of immunoglobulin genes encoding a pathogenic autoantibody in murine lupus" (1990) J. Clin. Invest. 85:530-540.
Voss, E.W. Jr., Anti-DNA antibodies in SLE. (1990) E.W. Voss, Jr., ed. Crc Press, Boca Raton, FL. A title page and table of contents were originally submitted.
Wang, H., et al., "Solution structure of a disulfide cross-linked DNA hairpin" (1994) J. Am. Chem. Soc. 116:5021-5022.
Watanabe-Fukunaga, R., et al., "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis" (1992) Nature 296:314-317.
Winter, G., et al., "Antibody-based therapy: Humanized antibodies" (1993) TIPS 14:139-143.
Oi et al., "Chimeric Antibodies" BioTechniques (1986) 4(3):214-221.
Ohnishi et al., "Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics" International Immunology (1994) 6(6):817-830.
Scheiner Laurie
The Regents of the University of Michigan
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