Therapeutic method

Details Therapeutic method Therapeutic method

2005-03-22

2005-03-22

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000, C424S093700

Reexamination Certificate

active

06869926

ABSTRACT:
The present invention relates to new therapeutic use of amylin as agent which stimulates chondrocyte proliferation and which therefore have utility in the treatment of cartilage disorders and/or cartilage mediated bone growth.

REFERENCES:
patent: 0 408 284 (1996-05-01), None
patent: WO 9602269 (1996-02-01), None
patent: 9707214 (1997-02-01), None
patent: 9738704 (1997-10-01), None
Fisher, J. A. et al. (2002) Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs). Biochem. Soc. Trans. vol. 30, pp. 455-460. Review.*
Christopoulos, G. et al. (1999) Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol. Pharmacol. vol. 56, pp. 235-242.*
Cornish, J. et al. (1998) Dissociation of the effects of amylin on osteoblast proliferation and bone resorption. Am J Physiol. vol. 274, pp. E827-E833.*
Ng. M. C. Y. et al. (2001) Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more significant roles than autoimmunity. Diabetes Care. vol. 24, pp. 663-671.*
Cornish et al., “Adrenomedullin is a Potent Simulator of Osteoblastic Activity In Vitro and In Vivo”, American Journal of Physiology 273:E113-E1120, 1997.
Cornish et al., “Dissociation of the Effects of Amylin on Osteoblast Proliferation and Bone Resorption”, American Journal of Physiology 274:E827-E833, 1998.
Cornish et al., “Systemic Administration of Amylin Increases Bone Mass, Linear Growth, and Adiposity in Adult Male Mice”, American Journal of Physiology 275:E694-E699, 1998.
Reid et al, “Amylin and CGRP”, Principles of Bone Biology pp 495-505, 1996.

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