Therapeutic liposome composition and method of preparation

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S401000

Reexamination Certificate

active

07122202

ABSTRACT:
Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting conjugates composed of a lipid, a hydrophilic polymer and a targeting ligand. The therapeutic, target-cell sensitized liposome composition is formed by incubating the liposomal composition with a selected conjugate.

REFERENCES:
patent: 4913902 (1990-04-01), Kilpatrick et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5370993 (1994-12-01), Tarnowski et al.
patent: 5395619 (1995-03-01), Zalipsky
patent: 5534241 (1996-07-01), Torchilin
patent: 5603872 (1997-02-01), Margalit
patent: 5620689 (1997-04-01), Allen
patent: 5631018 (1997-05-01), Zalipsky
patent: 5891468 (1999-04-01), Martin et al.
patent: 5932462 (1999-08-01), Harris
patent: 5985852 (1999-11-01), Nagy et al.
patent: 6120798 (2000-09-01), Allen et al.
patent: 7173079 (1995-07-01), None
patent: WO 94/21281 (1994-09-01), None
Duzgunes, N., et al., “Fusion of Liposomes Containing a Novel Cationic Lipid, N>2,3-(Dioleyloxy)propyl-N,N,N,-trimethylammonium: Induction by Multivalent Anions and Asymmetric Fusion with Acidic Phospholipid Vesicles,”Biochemistry,28:9179-9184 (1989).
Kirpotin, D., et al., “Liposomes with Detachable Polymer Coating: Destabilization and Fusion of Dioleoylphosphatidylethanolamine Vesicles Triggered by Cleavage of Surface-Grafted poly(ethylene glycol),”FEBS Letters,388:115-118 (1996).
Naka, K., et al., “Molecular Harpoons: Membrane-Disrupting Surfactants that Recognize Osmotic Stress,”J. Am. Chem. Soc.,114:4011-4013 (1992).
Topchieva, I.N. and Efremova, N. V., “Conjugates of Proteins with Block Co-polymers of Ethylene and Propylene Oxides,”Biotechnology and Genetic Engineering Reviews,12:357-382 (1994).
Kirpotin, D.B., et al., “Targeting of Liposomes to Solid Tumors: The Case of Sterically Stabilized Anti-HER2 Immunoliposomes,”Journal of Liposome Research,07(04):391-417 (1997).
Park, J.W., et al., “Development of anti-p185.sup.HER2 Immunoliposomes for Cancer Therapy,”Proc. Natl. Acad. Sci. USA,92:1327-1331 (1995).
Uster, P.S., et al., “Insertion of Poly(Ethylene Glycol) Derivatized Phospholipid into Pre-formed Liposomes Results in Prolonged in vivo Circulation Time,”FEBS Letters,386:243-246 (1996).
Zalipsky, S., et al., “Poly(Ethlyene Glycol)-Grafted Liposomes with Oligopeptide or Oligosaccharide Ligands Appended to the Termini of the Polymer Chains,”Bioconjugate Chem.,8:111-118 (1997).
Klibanov, A.L. et al., “Long-circulating liposomes: development and perspectives”,Journal of Liposome Research,2(3):321-334 (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic liposome composition and method of preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic liposome composition and method of preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic liposome composition and method of preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3623687

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.