Therapeutic insulin preparation and a process for the production

Details Therapeutic insulin preparation and a process for the production Therapeutic insulin preparation and a process for the production

1977-12-08

1980-01-15

Waddell, Frederick E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424178, A61K 3726

Patent

active

041838491

ABSTRACT:
Novel stable insulin preparations with protracted action and reduced or no antigenicity are obtained by reacting insulin free of antigenic impurities with an organic compound having basic amino groups, preferably a basic polypeptide or a cleavage product of a basic polypeptide, such as protamine, in a buffered protein dissociating or protein depolymerizing aqueous medium. Examples of preferred protein dissociating or protein depolymerizing media are aqueous solutions containing urea, a lower alkanol dialkylformamide, acetamide, N-alkyl-acetamide or acetonitrile.

REFERENCES:
patent: 2704737 (1955-03-01), Bischoff
patent: 3060093 (1962-10-01), Poulsen et al.
patent: 3868358 (1975-02-01), Jackson
patent: 3907676 (1975-09-01), Jorgensen

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