Therapeutic human albumin having a low aluminium binding capacit

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 6, 514 12, 530362, 530363, 530364, A61K 3816, C07K 1300

Patent

active

058469303

ABSTRACT:
There is described a therapeutic human albumin having a very low capacity for the absorption of aluminium, during storage in a glass receptacle, wherein the final composition of the albumin solution adjusted to be stable and isotonic at a concentration of 5, 20 or 25% of protein in an aqueous medium, preferably, or to any other therapeutic concentration acceptable for intravenous administration, has a citrate content in the final albumin composition equal to or less than 0.5 mM (millimolar) and, preferably, less than 0.037 mM (millimolar).

REFERENCES:
patent: 4086222 (1978-04-01), Lindquist et al.
Klein, Gordon L.: Aluminum in Parenteral Products: Medical Perspective on Large and Small Volume Parenterals. Journal of Parenteral Science & Technology, 43 (3), 120-124 (1989).
Cuthbertson. B. et al.: Aluminium and Human Albumin Solutions. British Medical Journal, 295,1062 (1987).

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