Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-07-21
1999-11-09
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530402, 525 541, 525 542, 536 41, 536 185, 536 186, 536123, 5361231, 53612313, 536126, 514 23, 514 25, 514 54, 514 55, A61K 3514, C07G 300, A01N 4304
Patent
active
059817100
ABSTRACT:
Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.
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Hai Ton That
Nelson Deanna J.
Pereira David E.
Baxter International Inc.
Mohamed Abdel A.
Tsang Cecilia J.
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