Therapeutic furopyrimidines and thienopyrimidines

Details Therapeutic furopyrimidines and thienopyrimidines Therapeutic furopyrimidines and thienopyrimidines

2006-01-16

2008-09-30

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S045000, C536S027130

Reexamination Certificate

active

07429571

ABSTRACT:
The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

REFERENCES:
patent: 4584369 (1986-04-01), Klein et al.
patent: 6339089 (2002-01-01), Nakashima et al.
patent: 2006/0234963 (2006-10-01), Babu et al.
patent: 0 071 227 (1983-02-01), None
patent: WO 97/29110 (1997-08-01), None
patent: WO 98/08847 (1998-03-01), None
patent: WO 98/49899 (1998-11-01), None
patent: WO 03/051899 (2003-06-01), None
patent: WO 03/093290 (2003-11-01), None
patent: WO 2004/058792 (2004-07-01), None
patent: WO 2005/123087 (2005-12-01), None
patent: WO 2006/050161 (2006-05-01), None
De Clerq Nature Reviews: Microbiology (2004), vol. 2, pp. 704-720.
Alexander et al., “(Acyloxy)alkyl carbamates as novel bioreversible prodrugs for amines: Increased permeation through biological membranes”,J Med Chem, 31(2), 318-322 (1988).
Blight et al., “Efficient initiation of HCV RNA replication in cell culture”,Science, 290, 1972-1974 (2000).
Bodor, “Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials”,J Med Chem, 23(5), 469-474 (1980).
Bruenn, “Relationships among the positive strand and double-strand RNA viruses as viewed through their RNA-dependent RNA polymerases”,Nucleic Acids Res, 19(2), 217-226 (1991).
Davis, “Current therapy for chronic hepatitis C”,Gastroenterology, 118, S104-S114 (2000).
Korba et al., “Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication”,Antiviral Res, 19(1), 55-70 (1992).
Lefebvre et al., “Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: Intracellular delivery of 3′-azido-2′,3′-dideoxythymidine 5′-monophosphate”,J Med Chem, 38(20), 3941-3950 (1995).
Okuse et al., “Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapy”,Antiviral Res, 65(1), 23-34 (2005).
International Search Report for International Application No. PCT/US2006/010948, mailed Sep. 7, 2006.
Bhattacharya et al., “Studies on the Synthesis of Furo [3,2-d] Pyrimidine C-Nucleosides: New Inosine Analogues with Antiprotozoan Activity”,Nucleosides&Nucleotides, 9(8), 1021-1043 (1990).
Bhattacharya et al., “Synthesis of Furo[3,2-d] Pyrimidine Nucleosides: A Novel C-Nucleoside Isostere of Adenosine”,Tetrahedron Letters, 27(7), 815-818 (1986).
Ikegami et al, “Structure of Pyrrolosine: A Novel Inhibitor of RNA Synthesis, from the ActinomyceteStreptomyces albus”, J. Am. Chem. Soc., 112, 9668-9669 (1990).
Jourdan et al., “Synthesis of Thieno[3,2-d] pyrimidine-2,4-diones Cyclic and Acyclic Nucleosides as Potential Anti HIV Agents”,J. Heterocyclic Chem., 31, 305-312 (1994).
Morris et al., “New Syntheses of 7-Substituted-2-aminothieno- and Furo[3,2-d] pyrimidines”,J. Heterocyclic Chem., 36, 423-427 (1999).
Otter et al., “A Corrected Structure for Pyrrolosine”,J. Am. Chem. Soc., 114, 668-671 (1992).
International Search Report for International Application No. PCT/US05/39072, mailed Oct. 17, 2007.
Girgis et al.,J. Med. Chem., 33, 2750-2755 (1990).

Affiliated with

Also associated with

Rating

Therapeutic furopyrimidines and thienopyrimidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic furopyrimidines and thienopyrimidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic furopyrimidines and thienopyrimidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3977535