Therapeutic fibrinogen compositions

Details Therapeutic fibrinogen compositions Therapeutic fibrinogen compositions

1994-04-08

1997-02-25

Weimar, Elizabeth C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530382, 530419, 530421, A61K 3800

Patent

active

056058870

ABSTRACT:
A therapeutic composition effective on contact with thrombin at a site of treatment in a patient as a tissue adhesive, hemostat or sealant, said composition comprising non-autologous, non-single donor mammalian fibrinogen that is capable of polymerizing when provided in solution at said site at a concentration of about 30 mg/ml thereof or less, to a fibrin network having therapeutically effective strength, wherein said composition contains less than about 30% (w/w), based on total protein mass present therein, of proteins other than fibrinogen, and further comprises a sufficient amount of one or more low molecular weight physiologically-compatible solutes such that said composition, if formulated as a lyophilized material, can be reconstituted therefrom at room temperature in sterile water for injection in about 30 minutes or less, at about 25 mg/ml of said fibrinogen. Additionally, methods for producing and maintaining said composition, and methods for the use thereof.

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