Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2008-10-09
2011-11-29
Saoud, Christine J (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000, C435S007100
Reexamination Certificate
active
08067373
ABSTRACT:
The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1and R2are either the same or different, wherein R1and R2are each selected from the group consisting of hydrogen and a saturated or unsaturated hydrocarbon residue, said residue having from 1 to 10 carbon atoms, wherein Z1is selected from the group consisting of histidine and proline, wherein Z2is selected from the group consisting of an arginine and a peptide comprising an initial arginine and having from 2 to 30 amino acids. The invention also relates to methods using the peptides of the present invention in the treatment of inflammation.
REFERENCES:
patent: 4927916 (1990-05-01), Matsueda et al.
patent: 5720934 (1998-02-01), Dean et al.
patent: 7271144 (2007-09-01), Petzelbauer
patent: 7494973 (2009-02-01), Petzelbauer
patent: 2003/0078613 (2003-04-01), Heidner
patent: 19729591 (1999-02-01), None
patent: WO 93/21962 (1993-11-01), None
patent: WO 02/48180 (2002-06-01), None
Fiotti et al. (1999)., Atherosclerosis 145, pp. 51-60.
Blomback et al., N-Terminal Disulphide Knot of Human Fibrinogen 1968Nature218:130-4.
Engelhart et al., Surveilance for Nonsocialcomical Infections and Fever of Unknown Origin Among Adult Heotology-Oncology Patients 1984Chromotography19:77.
Everse, S. J., Conformational Changes in Fragments D and Double-D from Human Fibrin(ogen) Upon Binding the Peptide Ligand Gly-His-Arg-Pro-Amide 1999,Biochemistry, Bd. 38(18):2941-46.
Harenberg, J. Biodistribution of Human Fibrinogen-derived Peptides in Rabbits 1983Fibrinogen: Struct. Variants Interact. 271-8.
Henschen et al., High Performance Liquid Chromotography 1985VCH.
Herrick et al., Role of Plasminogen Activators in Peritoneal Adhesion Formation. 1999Fibrinogen, International Journal of Biochemistry and Cell Biology, Bd. 31:741-6.
Ikematsu, Radioimmunoassay of Fibrinopeptide 1984 Bd. 28, Nr. 1, 20-24, Table 2.
Kawasaki, K., Amino Acids and Peptides XII: Synthetic Peptides Related to the N-Terminal Portion of Fibrin Alpha-chain and their Inhibitory Effects on Fibrinogen/ Thrombin Clotting. 1989Thrombosis Research, Bd. 56:757-62.
Kunstfield et al., HECA-452 T Cells Migrate Through Superficial Vascular Plexus But Not Through Deep Vascular Plexus Endothelium, 1999,J. Immunol. Method222:101-9.
Merrifield, R. B., Solid Phase Peptide Synthesis 1963J. Amer. Chem. Soc. 85:2149-54.
Nieuwenhuizen et al., Plasminogen Activation by Tissue Activator Is Accelerated in the Presence of Fibrin(ogen) Cyanogen Bromide Fragment FCB-2 1983Biochem. Biophys. Acta. 755:531-3.
Nuzzo et al., Thermal Decomposition of Di(cycloalkyl)bi(triethylphosphine)platinum(II) Complexes 1981)J. Amer. Chem. Soc. 37:3404-9.
Petzelbauer et al., Human Delayed-Type Hypersensitivity Reaction in a SCID Mouse Engrafted With Human T-Cells and Autologous Skin 1996J. Invest. Dermatol. 107:576-81.
Skogen et al., Fibrogen-Derived Peptide B 1-42 Is a Multidomained Neutrophil Chemoattractant 1988Blood71:1475-79.
Fibrex Medical Research & Development GmbH
Maschoff Gilmore & Israelsen
Saoud Christine J
Seharaseyon Jegatheesan
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