Therapeutic fibrin-derived peptides and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07494973

ABSTRACT:
The invention relates to peptides having the general formula (I), or a salt or amide thereof, wherein R1and R2are either the same or different, wherein R1and R2are each selected from the group consisting of hydrogen and a saturated or unsaturated hydrocarbon residue, said residue having from 1 to 10 carbon atoms, wherein Z1is selected from the group consisting of histidine and proline, wherein Z2is selected from the group consisting of an arginine and a peptide comprising an initial arginine and having from 2 to 30 amino acids. The invention also relates to methods using the peptides of the present invention in the treatment of inflammation.

REFERENCES:
patent: 4927916 (1990-05-01), Matsueda et al.
patent: 5720934 (1998-02-01), Dean et al.
patent: 2003/0078613 (2003-04-01), Heidner
patent: 19729591 (1999-02-01), None
patent: WO/93/21962 (1993-11-01), None
patent: WO/02/48180 (2002-06-01), None
Everse, S. J. (1999). Conformational Changes in Fragments D and Double-D from Human Fibrin(ogen) Upon Binding the Peptide Ligand Gly-His-Arg-Pro-Amide. Biochemistry, Bd. 38, 18: 2941-2946.
Gröger et al. (1999). J. Immunol. Method, 222: 101-109.
Herrick, S. et al. (1999). Fibrinogen, International Journal of Biochemistry and Cell Biology, Bd. 31: 741-746.
Petzelbauer et al. (1996). J. Invest. Dermatol., 1996, 107: 576-581.
Kawasaki, K. (1989). Amino Acids and Peptides XII: Synthetic Peptides Related to the N-Terminal Portion of Fibrin Alpha-chain and their Inhibitory Effects on Fibrinogen/ Thrombin Clotting. Thrombosis Research, Bd. 56: 757-762.
Skogen, W. F. et al. (1988). Blood 71: 1475-1479.
Henschen et al. (1985). High Performance Liquid Chromotography VCH.
Engelhart et al. (1984). Chromotography, 19: 77.
Ikematsu. (1984). Radioimmunoassay of Fibrinopeptide, Bd. 28, Nr. 1, 20-24, Table 2.
Harenberg, J. (1983). Biodistribution of Human Fibrinogen-derived Peptides in Rabbits. Fibrinogen: Struct. Variants Interact., 271-278.
Nieuwenhuizen et al. (1983). Biochem Biophys Acta, entitled Plasminogen activation by tissue activator is accelerated in the presence of fibrin(ogen) cyanogen bromide fragment FCB-2, 755: 531-533.
Carpino et al. (1981). J. Amer. Chem. Soc., 37: 3404-3409.
Blomback et al. (1968). Nature, entitled N-Terminal Disulphide Knot Of Human Fibrinogen, 218: 130-134.
Merrifield, R. B. (1963). J. Amer. Chem. Soc., 85: 2149-2154.

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