Therapeutic enzyme-antibody complexes

Details Therapeutic enzyme-antibody complexes Therapeutic enzyme-antibody complexes

1987-04-13

1991-04-23

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 858, 424 9463, 424 9464, 435188, 435212, A61K 3754, A61K 39395, C12N 996

Patent

active

050098888

ABSTRACT:
A complex of a therapeutically effective enzyme and a monoclonal antibody specific for the enzyme, the antibody being bound to the enzyme by immunoaffinity, the K.sub.D of the antibody/enzyme complex being at least 10.sup.-11 M, or by covalent bonding the antibody being bound to the enzyme at a site on the enzyme which does not substantially interfere with the activity of the enzyme and which increases the in vivo half-life of the enzyme.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4285932 (1981-08-01), Smith
Zyk, "Modification of L-Asparaginase EC-2 by Homologous Antibodies", BBA 302: 420-428 (1973).
Sevilla et al., Biochem. Biophys. Res. Comm., "Plasminogen Activator-Anti-Human Fibrinogen Conjugate", 130: 91-96 (1985).
Maksimenko et al., Thromb. Res., "Water-soluble Urokinase Derivatives of Combined Action", 38: 277-288 (1985).
Maksimenko et al., Thromb. Res., "Water-soluble Urokinase Derivatives with Increased Affinity to the Fibrin Clot", 38: 289-295 (1985).
Rosenblum et al., Cancer Res., "Modification of Human Leukocyte Interferon Pharmacology with a Monoclonal Antibody", 45: 2421-2424 (1985).

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