Therapeutic drug delivery systems

Details Therapeutic drug delivery systems Therapeutic drug delivery systems

1993-06-11

1996-12-03

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127

Patent

active

055805752

ABSTRACT:
Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.

REFERENCES:
patent: 3532500 (1970-10-01), Priest et al.
patent: 3873564 (1975-03-01), Schneider et al.
patent: 4049388 (1991-09-01), Knight et al.
patent: 4089801 (1978-05-01), Schneider
patent: 4162282 (1979-07-01), Fulwyler et al.
patent: 4187433 (1988-01-01), Feinstein
patent: 4192859 (1980-03-01), Mackaness et al.
patent: 4224179 (1980-09-01), Schneider
patent: 4229360 (1991-11-01), Schneider et al.
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4310505 (1982-01-01), Baldeschwieler et al.
patent: 4315514 (1982-02-01), Drewes et al.
patent: 4331654 (1982-05-01), Morris
patent: 4344929 (1982-08-01), Bonsen et al.
patent: 4426330 (1984-01-01), Sears
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hilmann et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4534899 (1985-08-01), Sears
patent: 4544545 (1985-10-01), Rayan et al.
patent: 4569836 (1986-02-01), Gordon
patent: 4572203 (1986-02-01), Feinstein
patent: 4586512 (1985-05-01), Do-huu et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4620546 (1986-11-01), Aida et al.
patent: 4646756 (1987-03-01), Watmough et al.
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4658828 (1987-04-01), Dory
patent: 4675310 (1987-06-01), Chapman et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4689986 (1987-09-01), Carson et al.
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4728578 (1988-03-01), Higgins et al.
patent: 4737323 (1988-04-01), Martin et al.
patent: 4774958 (1988-10-01), Feinstein
patent: 4776991 (1988-10-01), Farmer et al.
patent: 4781871 (1988-11-01), West, III et al.
patent: 4790891 (1988-12-01), Halliday et al.
patent: 4830858 (1989-05-01), Payne et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4863717 (1989-09-01), Keana
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4877561 (1989-10-01), Iga et al.
patent: 4893624 (1990-01-01), Lele
patent: 4895719 (1990-01-01), Radhakvishnau
patent: 4898734 (1990-02-01), Mathiowitz
patent: 4900540 (1990-02-01), Ryan
patent: 4921706 (1990-05-01), Roberts et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4938947 (1990-07-01), Nicolau et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 5000960 (1991-03-01), Wallach
patent: 5008050 (1991-04-01), Cullis et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5045304 (1991-09-01), Schneider et al.
patent: 5088499 (1992-02-01), Unger
patent: 5144703 (1992-05-01), Wolf et al.
patent: 5149319 (1992-09-01), Unger
patent: 5171755 (1992-12-01), Kaufman
patent: 5194266 (1993-03-01), Abra et al.
patent: 5195520 (1993-03-01), Schlief et al.
patent: 5198225 (1993-03-01), Meybeck et al.
patent: 5209720 (1993-05-01), Unger
patent: 5213804 (1993-05-01), Martin et al.
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5219538 (1993-06-01), Henderson et al.
patent: 5271928 (1993-12-01), Schneider
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5316771 (1994-05-01), Barenholtz et al.
patent: B14229360 (1980-10-01), Schneider et al.
Kost et al. Ultrasonic Modulated Drug Delivery Systems Polymers in Medicine II Plenum Press New York 387-396.
Brown et al. Transdermal Delivery of Drugs Ann. Rev. Med. 1988 39:221-229.
Santaella et al. Extended in vivo blood circulation time of fluorinated liposomes FEBS 1993 336:481-484.
Gramiak et al., Radiology, "Detection of Intracardiac Blood Flow by Pulsed Echo-Ranging", pp. 415-418 (1971).
Feigenbaum et al., Circulation, "Identification of Ultrasound Echoes from the left Ventricle by Use of Intracardiac Injections of Indocyanine Green", vol. XL1, pp. 615-621 (1970).
Stelmashok et al., Koordinatsionnaya Khimiya, vol.3, No. 4, pp. 524-527 (1977) (Russian language version).
Fitzpatrick et al. Metal Ion Catalyzed Decarboxylation: Kinetics and Mechanism fo the Oxidative Decarboxylation of Copper (II) Complexes of Aminomalonic Acid in Aqueous Solution Inorganic Chem. 1974 13:568-574.
Thanassi Aminomalonic Acid: Spontaneous Decarboxylationand reaction with 5-Deoxpyridoxal Biochemistry 1970 9:525-532.
Stelmashok et al. Koordinatsionnaya Khimiya 1977 3:524-527 (English Verison).
Jain et al. Introduction to Biological Membranes Ch. 9 192-231 J. Wiley and Sons, NY 1980.
Sigel H. Ed., Metal Ions in Biological Systems: Antibiotics and Their Complexes vol. 19 Marcell Dekker NY 1985.
Nayar et al. Generation of Large Unilamellar Vesicles From Long-Chanin Saturated Phosphtidylcholines by Extrusion Techniques Biochimica et Biophysica Acta 1989 986:200-206.
Hope et al. Generation of Multilamellar and Unilamellar Phospholipid Vesicles Chem. Phys. of Lipids 1986 40:89-107.
Mattrey et al. Perfluorochemicals as US Contrast Agents for Tumor-Imaging and Hepatosplenography: Preliminary Clinical Results Radiology 1987 163 339-343.
Mattrey et al. Perfluorocytlbromide: A Liver/Spleen-Specific and Tumor Imaging Ultrasound Contrast Material Radiology 1982 145:759-762.
Keller et al. Successful Left Ventricular Opacification Following Peripheral Venous Injection of Sonicated Contrast Agent LV Contrast Echocardiography 1987 114:570-575.
Feinstein et al. Two-Dimensional Contrast Echocardiography I JACC 1984 3:14-20.
Ten Cate et al. Two-Dimensional Contrast Echocardiography II JACC 1984 3:21-27.
Unger et al. Hepatic Metastases: Lipsomal Gd-DTPA-enhanced MR Imaging Radiology 1989 171:81-85.
Deamer et al. Permeability of Lipid Bilayers to Water and Ionic Solutes Chem. Phys. Lipids 1986 40:167-188.
Gutknecht et al. Diffusion of Carbon Dioxide Through Lipid Bilayer Membranes Chemical Abstracts 1977 87:34772q.
Scarpa et al. Cation Permeability of Liposomes as a Function of the Chmical Composition of the Lipid Bilyares Biochimica et Biophysica Acta 1971 241 :789-797.
MacNaughton et al. Effects of Gaseous Anesthetics and Inert Gases on the Phase Transition in Smectic Mesophases of Dipalmitoyl Phosphatidylcholine Biochim. et Biophy. Acta 1980 597:193-198.
Tilcock et al. Liposmal GD-DTPA Radiology 1989 171:77-80.
Mann et al. Formation of IRon Oxides in Unilamellar Vesicles Journal of Colloid and Interface Science 1988 122:326-335.
Anderson et al. Manganese (III) Complexes in Oxidative Decarboxylation of Acids J. Am. Chem. COs. 1970 92:2450-2460.
Muhlradt et al. Vitamin B6 Analogs New Compounds 1967 10:129-130.
Chapman D. Physiochemical Properties of Phopholipids and Lipid Water Systems Liposome Technology 1984 1:1-19.
Violante et al. Particulate Suspensions as Ultrasonic Contrast Agents for Liver and Spleen Inv. Rad. 1988 23:S294-S297.
Fritzsch et al. Preclinical and Clinical Results with an Ultrasonic Contrast Agent Inv. Rad. 1988 23:S302-S305.
Brochure, Experience, Sonicator, Heat Systems Ultrasonics, Inc. 1987.
Ostro M. Liposomes Marcel Dekker New York 1983 102-103.
Rose A. et al. The Condensed Chemical Dictionary Reinhold Publishing New York 1966 728 and 743.
Belykh A. G. Farmakol Toksikol (MOSC) 1981 44:322-326.
Vion-Dury et al. J. Pharmacol. Exper. Ther. 1989 250:1113-1118.
Zalutsky et al. Invest. Radiol. 1987 22:141-147.
Scientific Apparatus Catalog 92/93 (VWR Scientific, 1991) Syringes pp. 1511 -1513, Filtration, Syringe Filters pp. 766-768, Filtration, membranes pp. 750-753; Filtration, Filters Holders p. 744.
Acoustic Imaging; AI5200; Convex Curved Linear Array Ultrasound Transducers Operator's Manual, Nov. 20, 1989, 4700-0003-IC, p. 4.
Bangham et al., "Diffusion of Univalent Ions across the Lamellae of Swollen Phospholipids", J. Mol. Biol., 1965, 13:238-252.
Carson et al., Ultrasound in Med. & Biol. 3, 1978, 341-350.
Chapman et al., "Biomembrane Phase Transitions", J. Biol. Chem., 1974, 249:2512-2521.
deGier et al., "Relations Between Liposomes and Bio

Affiliated with

Also associated with

Rating

Therapeutic drug delivery systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic drug delivery systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic drug delivery systems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-783391