Therapeutic domains of van Willebrand factor

Details Therapeutic domains of van Willebrand factor Therapeutic domains of van Willebrand factor

1992-02-26

1999-05-04

Jacobson, Dian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530829, 536 235, 514822, C07K 14745, C12N 1512, A61K 3836

Patent

active

059004762

ABSTRACT:
A polypeptide which is capable of inhibiting binding of von Willebrand factor (vWF) to platelets and comprising an amino acid sequence that corresponds to the amino acid sequence of that fragment of mature von Willebrand factor subunit having its amino terminus at about Cys.sup.509 and its carboxy terminus at about Cys.sup.695, said polypeptide comprising optionally a second and/or a third domain, the second domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Thr.sup.450 and its carboxy terminus at about Tyr.sup.508, or a subfragment or combination of subfragments thereof, and a third domain corresponding to the amino acid sequence of that fragment of mature vWF subunit having its amino terminus at about Asp.sup.696 and its carboxy terminus at about Gly.sup.727, or a subfragment or combination of subfragments thereof; and also a process for producing said polypeptides from encoding DNA sequences, and also a method of inhibiting or treating thrombosis in a patient which comprising administering to such patient an effective amount of a therapeutic composition comprising one or more polypeptides of the invention.

REFERENCES:
patent: 4518584 (1985-05-01), Mark et al.
patent: 4959314 (1990-09-01), Merk et al.
Bonthron, D. et al. Nucl. Acids Res., 14(17), 7125-7127 (1986).
Fujimura, Y. et al. J. Biol. Chem., 261(1), 381-385 (1986).
Fujimura, Y. et al., J. Biol. Chem., 262, 1734-1739 (1987).
Ware, J. et al., Proc. Natl. Acad. Sci. USA, 88, 2946-2950 (1991).
Read, et al. Proc. Natl. Acad. Sci., 75, 4514-4518 (1978).
Cooney, K.A. et al., Blood, 76 (supp. 1) Abstract 1661, p. 418a, Nov. 15, 1990.
Gralnick, H.R. et al., Oral Communications on von Willebrand Factor-Ib Interaction presented at meeting in Amsterdam, the Netherlands, Abstract 536, p. 840, Jul. 5, 1991.
Mancuso, D.J. et al. J. Biol. Chem., 264(33), 19514-19527, Table V, (1989).
Andrews, R.K. et al., Biochemistry, 28, 8317-8326 (1989).
Lynch, D.C. et al., Cell, 41, 49-56 (1985).
Handa, M. et al., J. Biol. Chem., 261(27), 12579-12585 (1986).
Azuma, H. et al., J. Biol. Chem., 266(19), 12342-12347 (1991).
Mohri, H. et al., J. Biol. Chem., 263(34), 17901-17904 (1988).
Hanahan, D., J. Mol. Biol., 166, 557-580 (1983).
Vicente, V. et al., J. Biol. Chem., 265, 274-280 (1990).
Sugimoto, M. et al., Biochemistry, 30(21), 5202-17 (1991).
Rosenberg, A.H. et al., Gene, 56, 125-136 (1987).
Newman, P.J. et al. J. Clin. Invest., 82, 739-743 (1988).
Kunkel, T.A., Proc. Natl. Acad. Sci. USA, 82, 488-492 (1985).
Fulcher, C.A. et al. Proc. Natl. Acad. Sci. USA, 79, 1648-1652 (1982).
Craik, C. "Use of Oligonucleotides for site Specific Mutagenesis", Biotechniques, Jan./Feb. 1985 at p. 12.
Mohri et al. "Isolation of the von Willebrand . . . " JBC Oct. 15, 1989 vol. 264, pp. 17361-17367.
Lerner "Tapping the immunization . . . " No date 799 Oct. 14, 1982 pp. 592-595.

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