Therapeutic dentifrices in unlined container and methods

Special receptacle or package – With specified material for container or content – For content inhibitor or stabilizer

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424 52, A61K 718, B65D 8124, B65D 8126, B65D 8514

Patent

active

041592808

ABSTRACT:
The corrosion and staining of unlined aluminum tube surfaces by dentifrices such as toothpastes, particularly when the dentifrices contain therapeutic agents, is substantially prevented by incorporation into the dentifrice of a controlled amount of an alkaline earth metal ion such as calcium ion, in the range of 0.005-0.2 weight percent, and preferably in the range of 0.005-0.070 weight percent of the dentifrice. The alkaline earth metal may be provided from any water soluble alkaline earth metal salt or as a reaction product of the alkaline earth metal salt with an amorphous silica abrasive and/or thickener.

REFERENCES:
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Degussa Technical Bulletin Pigments No. 9 "Synthetic Products for Toothpastes" 12 pp. (1970).
Degussa Technical Bulletin No. 49 "Aerosil.RTM. in Pharmaceuticals and Cosmetics" reprint from Drugs made in Germany, vol. 13, pp. 47-58, 108-117 (1970), p. 3, part 3.7 Preventing Corrosion-Toothpaste Tubes.

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