Therapeutic delivery using compounds self-assembled into high ax

Details Therapeutic delivery using compounds self-assembled into high ax Therapeutic delivery using compounds self-assembled into high ax

1996-11-21

1998-12-22

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

424450, A61K 900, A61K 9127

Patent

active

058515364

ABSTRACT:
Therapeutic agents comprising plural therapeutic compounds self assembled into high axial ratio microstructures are described. The threapeutic compounds satisfy the formula HARFM-Th, wherein HARFM is a high axial ratio forming material and Th is a therapeutic associated with the HARFM. The therapeutic agent also can satisfy the formula HARFM-S-Th, wherein S is a spacer. Release of the therapeutic by the agent generally follows either 0-order kinetics or psuedofirst order kinetics. A method for delivering drugs to animals or persons also is described. The method comprises administering an effective amount of a therapeutic self-assembled into an HAR microstructure to the animal or person.

REFERENCES:
patent: 4871488 (1989-10-01), Mannino
patent: 4990291 (1991-02-01), Schoen
patent: 5643574 (1997-07-01), Gould-Fogerite
Tovchilin in BBRC. 85, #3, pp. 983-990, Dec. 1978.

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