Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-05-16
2006-05-16
Azpuru, Carlos A. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S434000, C424S435000, C424S436000, C424S451000, C424S464000
Reexamination Certificate
active
07045140
ABSTRACT:
Metal carbonyls are used to deliver CO having biological activity, for example vasodilatation and inhibition of transplant rejection. The metal of the carbonyl is typically of groups 7 to 10, e.g. Fe and Ru. The carbonyl preferably has one or more ligands other than CO, such as amino acids, to modulate the CO release property and solubility.
REFERENCES:
patent: 5882674 (1999-03-01), Herrmann et al.
patent: 2002/0155166 (2002-10-01), Choi et al.
patent: 211 084 (1990-04-01), None
patent: WO 91/01128 (1991-02-01), None
patent: WO 91/01301 (1991-02-01), None
patent: WO 94/22482 (1994-10-01), None
patent: WO 95/05814 (1995-03-01), None
patent: WO 98/29115 (1998-07-01), None
patent: WO 98/48848 (1998-11-01), None
patent: WO 00/56743 (2000-09-01), None
patent: WO 02/078684 (2002-10-01), None
patent: WO 02/080923 (2002-10-01), None
patent: WO 03/000114 (2003-01-01), None
patent: WO 03/0666067 (2003-08-01), None
patent: WO 03/072024 (2003-09-01), None
patent: WO 03/088923 (2003-10-01), None
patent: WO 03/088981 (2003-10-01), None
patent: WO 03/094932 (2003-11-01), None
Furchgott, et al, Blood Vessels 1991;28:52-61 “Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light”.
Wang et al, Biochemistry, vol. 18, No. 22, 1979, 4960-4977 “A Correlation of the Visible and Soret Spectra of Dioxygen- and Carbon Monoxide-Heme Complexes and Five-Coordinate Heme Complexes with the Spectra of Oxy-, Carboxy-, and Deoxyhemoglobins”.
Schubert, Nov., 1933 Carbon Monoxide on Iron and Cobalt Cysteine Complexes, vol. 55, 4563-4570 “The Action of Carbon Monoxide on Iron and Cobalt Complexes of Cysteine”.
Carroll et al, Can. J. Chem. vol. 52, 1974, 1914-1922 “Ligand Abstraction in the Reaction of Aryldiazonium Ions with some Iron Complexes Containing Coordinated Cysteine, Maleonitriledithiol, or Triarylphosphine”.
Sjöstrand, Scan. J. Clin. Lab Invest., 1949, 1:201-214 “Endogenous Formation of Carbon Monoxide In Man Under Normal and Pathological Conditions”.
Coburn et al, J. of Clinical Investigation, vol. 42, No. 7, 1963, 1172-1178 “Endogenous Carbon Monoxide Production in Man”.
Tenhunen et al, J. of Biological Chemistry, vol. 244, No. 23, 6388-6394 (1969) “Microsomal Heme Oxygenase”.
Maines, Dept. of Biophysics, University of Rochester, FASEB J 2:2557-2568 (1988) “Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications”.
Morita et al, Proc. Natl. Acad. Sci. USA, Cell Biology, 1995, vol. 92, 1475-1479, “Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP”.
Sammut et al, British J. of Pharmacology, 1998, 125, 1437-1444 “Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1”.
Maines, Annu. Rev., Pharmacol. Toxocol, 1997, 517-554, “The Heme Oxygenase System: A Regulator of Second Messenger Gases”.
Soares et al, Nature Medicine, vol. 4, No. 9, 1998, 1073-1077, “Expression of heme oxygenase-1 can determine cardiac xenograft survival”.
Willis et al, Nature Medicine, vol. 2, No. 1, 1996, 87-90 “Heme oxygenase: A novel target for the modulation of the inflammatory response”.
Motterlini et al, Regulation of Pressor Responses by HO-1-Derived CO, 1998, 568-577 “Heme Oxygenase-1-Derived Carbon Monoxide Contributes to the Suppression of Acute Hypertensive Responses In Vivo”.
Otterbein et al, Am. J. Physiol., 1999, 688-694 Carbon monoxide provides protection against hyperoxic lung injury.
Otterbein et al, J. Clin. Invest., 103; 1047-1054, 1999, “Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury”.
Herrick et al, Inorg. Chem. 1984, 23, 4550-4553 “Flash Photolytic Investigation of Photoinduced Carbon Monoxide Dissociation from Dinuclear Manganese Carbonyl Compounds”.
Alessio et al, Inorg. Chem., 1995, 34, 4722-4734 “Carbonyl Derivatives of Chloride-Dimethyl Sulfoxide-Ruthenium (II) Complexes: Synthesis, Structural Characterization, and Reactivity of RU(CO)x(DMSO)4−xCI2Complexes (x=1-3)”.
Sato et al, The J. of Immunology, 2001, 4185-4195, “Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants”.
Pneumatikakis et al, Inorganica Chimica Acta, 151, 1988, 243-248 “Interactions of Bis-[μ-chloro-chlorotricarbonylruthenium(II) and poly-[μ-dichloro-dicarbonylruthenium (II] with Nucleotides”.
Yan et al, Pharmazie, 2000, 55(4), 307-313 “Cytotoxicity of rhenium (I) alkoxo and hydroxo carbonyl complexes in murin and human tumor cells”.
Becker et al, Medical Sciences (1979), vol. 15, No. 2, 147-150, “Age related changes in antibody dependent cell mediated cytotoxicity in mouse spleen”.
Nagai et al., Biochemistry, 1991, vol. 30, No. 26, 6495-6503, “Unusual CO Bonding Geometry in Abnormal Subunits of Hemoglobin M Boston and Hemoglobin M Saskatoon”.
Tomita et al., Inorganic and Nuclear Chemistry Letters 1968, vol. 4, 715-718 “Structure and Reaction of Bis(L-cysteinato)Dicarbonyliron(II)”.
Ferrier et al, J. of Molecular Structure 344, 1995, 189-193 “FTIR spectrometric study of geometrical isomers of dicarbonyl ferrobiscysteinate Influence of the counter cation”.
Szakács-Schmidt et al, Inorganica Chimica Acta, 198-200, 1992, 401-405 “Iron (II) thiolates as reversible-carbon monoxide carriers”.
Takács et al, Inorganic Chimica Acta, 166, 1989, 39-46 “Synthesis and Molecular Structure of Carbonyl Derivatives of Iron(II) Thiolates Containing Nitrogen-donor Ligands”.
Tomita et al, Inorg. Nucl. Chem. Letters vol. 4, 715-718, 1968, “Structure and Reaction of Bis(L-cysteinato)Dicarbonyliron(II)”.
Huang et al, J. Am. Chem. Soc., 1991, 113, 9141-9144 “Photolysis of the Histidine-Heme-CO Complex”.
Silver et al, Inorganica Chimica Acta, 91, 1984, 279-283 “Mossbauer Studies on Protoprophyrin IX Iron(II) Solutions Containing Sulphur Ligands and their Carbonyl Adducts. Models for the Active Site of Cytochromes P-450”.
Diamantis et al, Inorg. Chem., 1981, 20, 1141-1150 Preparation and Structure of Ethylenediaminetetraacetate Complexes of Ruthenium(II) with Dinitrogen, Carbon Monoxide, and other π-Acceptor Ligands.
Urban et al, J. of Organometallic Chemistry 517, 1996, 191-200 Metal complexes of biologically important ligands, LXXXVII α-Amino carboxylate complexes of palladium(II), iridium(III) and ruthenium(II) from chloro-bridged ortho-metallated metal compounds and [(OC)3Ru(Cl)(μ-Cl)]2.
Motterlini et al, Carbon Monoxide-Releasing Molecules: Characterization Of Biomedical And Vascular Activities, Circulation Research. 2002, vol. 90, No. 2, 1-8.
Motterlini, R. et al.; “Characterization of vasoactive effects elicited by carbon monoxide-releasing molecules,”; Journal of Vascular Research, Abstracts, 8thInternational Symposium on Mechanisms of Vasodilation; May 31—Jun. 3, 2001; 055.
Durante W.; “Heme Oxygenase-1 in Growth Control and its Clinical Application to Vascular Disease”; J. Cell. Physiol.; 2003; 195; 373-82.
Gordeuk, V. P. et al; “Carbonyl Iron Therapy for Iron Deficiency Anemia”; Blood; 1986; 67(3); 745-752.
Huebers, H. A. et al.; “Absorption of carbonyl iron”; J. Lab. Clin. Med.; 1986; 108; 473-8.
Sacks, P. V. et al.; “Comparative bioavailability of elemental iron powders for repair of iron deficiency anemia in rats. Studies of efficacy and toxicity of carbonyl iron”; The American Journal of Clinical Nutrition, 1978; 31;566-73.
Mann Brian Ernest
Motterlini Roberto Angelo
Azpuru Carlos A.
Hemocorm Limited
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