Therapeutic/cosmetic compositions comprising CGRP antagonists fo

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

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424401, 424 701, 424 47, 424489, 514 2, 514844, 514846, 514937, 5303871, 530300, A61K 39395

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060199679

ABSTRACT:
Topically applicable pharmaceutical/dermatological/cosmetic compositions well suited for the therapeutic treatment or care of sensitive human skin, hair, mucous membranes, nails and/or the scalp, in particular for reducing or avoiding the skin-irritant side effects of a variety of bioactive agents, for example the .alpha.-hydroxy acids, comprise a therapeutically/cosmetically effective amount of at least one calcitonin gene related peptide ("CGRP") antagonist, e.g., CGRP 8-37 or an anti-CGRP antibody.

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Hughes, Sr. et al. British J. Pharmacol. 104 (3):738-742, 1991.
Singh, P. et al. 1994. Critical Reviews in Theurapeutic Drug Carrier Systems 11:161-213.

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