Therapeutic conjugates of toxins and drugs

Details Therapeutic conjugates of toxins and drugs Therapeutic conjugates of toxins and drugs

1995-05-26

1997-02-11

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

4241781, 5303917, 5303919, A61K 39395, C07K 1900, C07K 1630, C07K 1620

Patent

active

056018258

ABSTRACT:
Provided are conjugates useful in cancer or infectious disease therapy. The conjugate is a drug or modified toxin which is a native toxin devoid of a functioning receptor binding domain and a protein which reacts with a substance associated with a targeted cell or pathogen. The targeted substance internalizes the conjugate into the cell cytoplasm, and the kills the cell. The protein prior to conjugation has at least one mercapto group which becomes a site for conjugation to the toxin or drug. Also provided are methods of therapy, methods for producing the conjugate and pharmaceuticals compositions of the conjugates.

REFERENCES:
patent: 4867793 (1989-09-01), Goers et al.
patent: 5541297 (1996-07-01), Hansen et al.
Hird et al., Cancer and Genes, pp. 183-189, (1990).
Harris et al., Tibtech, vol. 11:42, (1993).
Osband et al., Immunol. Today, vol. 11:193, (1990).
Wilkinson et al., Immunol. Lett., vol. 15:17, (1987).
Wileman et al., J. Pharm. Pharmacol., vol. 38:264, (1986).
Pastan et al., Cell, vol. 47:641, (1986).
Abuchowski et al., J. Biol. Chem., vol. 252:3582, (1977).
Pai et al., Jama, vol. 269:78, (1993).
Olsnes et al., Immunol. Today, vol. 10:291, (1989).
Spooner et al., Tibtech, vol. 8:189, (1990).
Zwierira, Stem Cells, vol. 11:144-153, (1993).
Jain, Scientific American, vol. 271:58, (1994).
Curti, Crit. Rev. Oncol./Hemalol, vol. 14:29-39, (1993).

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