Therapeutic compounds comprised of anti-Fc receptor antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

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4241351, 4241341, 4242771, 4241841, 4241921, 512 12, 5303873, A61K 39365, A61K 3900, A61K 3800, C12P 2108

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active

058372431

ABSTRACT:
Multispecific multivalent molecules which are specific to an Fc receptor (FcR), and therapeutic uses and therapeutic uses and methods for making the molecules are described.

REFERENCES:
Jung, Gundram, et al., (1991), "Target Cell-Induced T cell Activation with Bi-and Trispecific Antibody Fragments", Eur. J. Immunol., vol. 21, pp. 2431-2435.
Fanger, M. et al. (1994) "Production and Use of Anti-FcR Bispecific Antibodies" Immunomethods 4 (1): 72-81.
Repp, R. et al. (1994) "G-CSF Stimulated Neutrophils as Effector Cells In Immunotherapy With a Bispecific Antibody to FcgammaRI and to HER-2
eu (MDX210): Preclinicla Studies", Immunobiology, 191 (2-3): 250-25.
Mabondzo, A. et al. (1994) "Antibody-Dependent Cellular Cytotoxicity and Neutralization of Human Immunodeficiency Virus Type 1 By High Affinity Cross-Linking of gp41 to Human Macrophage Fc IgG Receptor Using Bispecific Antibody" Journal of General Virology, 75 (6): 1451-1456.
Chen, J. et al. (1995) "An Immunoconjugate of Lys3-Bombesin and Monoclonal Antibody 22 Can Specifically INduce FcgammaRI (CD64)-Dependent Monocyte-and Neutrophil-Mediated Lysis of Small Cell Carcinoma of the Lung Cells" Clinical Cancer Research, 1(4); 425-434.
Graziano, R. et al. (1995) "Construction and Characterization of a Humanized Anti-Gamma-lg Receptor Type I (Fcgamma RI) Monoclonal Antibody" The Journal of Immunology, 155 (10): 4996-5002.
Jawetz et al. Medical Microbiology 19th Edition 1991 p. 115 Immunology.

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