Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-06-26
2010-10-05
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S277000
Reexamination Certificate
active
07807685
ABSTRACT:
Compounds of formula (I) below are disclosed. Their use as medicaments is described, in particular for the treatment of pain or inflammation:wherein:when X=Y=Z=OH, R1is OCH2CF2CF3, phenoxy (substituted with 3-(4-trifluoromethylphenyl), 3,4-dichloro, (3-trifluoromethyl,4-fluoro), (3-trifluoromethyl,4-chloro), (3-chloro, 4-cyano), or 3,5-bis(trifluoromethyl)), 1-piperazinyl(4-(3,4-dichlorophenyl)), phenyl (substituted with 3,4-dichloro, 3,5-difluoro, 3,5-bis(trifluoromethyl) or 3,4,5-trifluoro) or 2-benzofuranyl; orwhen X=Y=OH and Z=OMe, R1is OCH3, OCH2CHF2, OCH2cyclopentyl, O-(2,5-difluorophenyl) or (S)-sec-butylamino; orwhen X=H and Y=Z=OH, R1is n-hexylamino or cyclopentylamino; orwhen (IV) X=Z=OH and Y=H, R1is cyclopentylamino;or a pharmaceutically acceptable salt thereof.
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Brown Giles A.
Chapman Emma J.
Higginbottom Michael
Horgan Viet-Anh A.
Savory Edward D.
CBT Development Limited
Edwards Angell Palmer & & Dodge LLP
Hsi Jeffrey
Saeed Kamal A
Shterengarts Samantha L
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