Therapeutic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S450000, C549S009000, C549S346000

Reexamination Certificate

active

07439264

ABSTRACT:
This invention to antagonists that inhibit transporters and receptors. The invention also relates to partial inhibitors of transporters and receptors that allow partial transport or partial binding of a compound to the transporter or receptor. The invention also relates to compounds that differentially prevent transport or binding through a transporter or to a receptor. The invention also relates to the use of these compounds for treating certain diseases and disorders.

REFERENCES:
patent: 5948933 (1999-09-01), Meltzer et al.
patent: 6525206 (2003-02-01), Meltzer et al.
patent: 6531483 (2003-03-01), Kuhar et al.
patent: 202 03 103 U 1 (2002-08-01), None
patent: 1 051 980 (2000-11-01), None
patent: WO 01/89524 (2001-11-01), None
patent: WO 02/32842 (2002-04-01), None
Zou et al., J. Med. Chem. (2001), vol. 44(25), pp. 4453-4461.
Meltzer et al., Biorg. Med. Chem. Letters (1999), vol. 9(6), pp. 857-862.
Koziowski et al., J. Med. Chem. (1995), vol. 38(16), pp. 3086-3093.
P. Meltzer, et al., “Design and Synthesis of an Irreversible Dopamine-Sparing Cocaine Antagonist,” Bioorganic & Medicinal Chemistry, vol. 10, No. 11, (Nov. 2002), pp. 3583-3591; XP-002313676.
Mu-Fa Zou, et al. “Novel Tropane-Based Irreversible Ligands for the Dopamine Transporter”, J. Med. Chem. 2001, 44, 4453-4461.

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